Results 31 to 40 of about 12,370 (174)

Executive Summary: Clinical Practice Guideline for Autosomal Dominant Polycystic Kidney Disease in China

Kidney Diseases, 2020
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, with a prevalence of 1/2,500–1/1,000, and it affects 1.25 million people in China.
Chang-Lin Mei, Cheng Xue, Sheng-Qiang Yu, Bing Dai, Jiang-Hua Chen, Ying Li, Li-Meng Chen, Zhang-Suo Liu, Yong-Gui Wu, Zhao Hu, Yan Zha, Hong Liu, Yong-Ze Zhuang, Chun Zhang, Xiang-Cheng Xiao, Yue Wang, Gui-Sen Li, Yi-Yi Ma, Lin Li   +18 more
doaj   +1 more source

Polycystin-2 Ion Channel Function and Pathogenesis in Autosomal Dominant Polycystic Kidney

Shengwu huaxue yu shengwu wuli jinzhan
Polycystin-2 (also known as PC2, TRPP2, PKD2) is a major contributor to the underlying etiology of autosomal dominant polycystic kidney disease (ADPKD), which is the most prevalent monogenic kidney disease in the world. As a transient receptor potential (
WANG Kai, HUANG Yuan, ZHOU Ce-Fan, TANG Jing-Feng, CHEN Xing-Zhen   +4 more
doaj   +1 more source

Development of atypical genes in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

, 2023
reservedIntroduzione: La malattia del rene policistico (PKD) è una malattia genetica caratterizzata principalmente dalla formazione di cisti a livello del parenchima renale e progressiva perdita della funzione renale determinando insufficienza renale ...
CRACCO, FRANCESCA
core  

Dietary Care for ADPKD Patients: Current Status and Future Directions [PDF]

, 2019
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic nephropathy, and tolvaptan is the only therapy available. However, tolvaptan slows but does not stop disease progression, is marred by polyuria, and most patients worldwide ...
García González , Miguel Ángel, Sol Carriazo, Maria Vanessa Perez-Gomez, Cordido Eijo, Adrian, Ortiz, A., Miguel Angel García-González, Ana Belen Sanz, Carriazo, S., Adrian Cordido, Sanz, A. B., Perez-Gomez, M. V., Alberto Ortiz, Maria Dolores Sanchez-Niño, Sanchez-Niño, M. D.   +13 more
core   +1 more source

Assessing Risk of Disease Progression and Pharmacological Management of Autosomal Dominant Polycystic Kidney Disease

Canadian Journal of Kidney Health and Disease, 2017
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disorder worldwide. The disease is characterized by renal cysts and progressive renal failure due to progressive enlargement of cysts and renal fibrosis. An estimated
Steven Soroka, Ahsan Alam, Micheli Bevilacqua, Louis-Philippe Girard, Paul Komenda, Rolf Loertscher, Philip McFarlane, Sanjaya Pandeya, Paul Tam, Daniel G. Bichet   +9 more
doaj   +1 more source

SNX9 Inhibits Cell Proliferation and Cyst Development in Autosomal Dominant Polycystic Kidney Disease via Activation of the Hippo-YAP Signaling Pathway

Frontiers in Cell and Developmental Biology, 2020
Autosomal dominant polycystic kidney disease (ADPKD) is a complex process, involving the alteration of multiple genes and signaling pathways, and the pathogenesis of ADPKD remains largely unknown.
Ai-Wen Shen, Li-Li Fu, Lu Lin, Bo Sun, Dong-Xu Song, Wu-Tao Wang, Yi-Hao Wang, Pei-Ran Yin, Sheng-Qiang Yu   +8 more
doaj   +1 more source

Characterization of Primary Cilia in Osteoblasts Isolated From Patients With ADPKD and CKD

JBMR Plus, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of chronic kidney disease (CKD) and leads to a specific type of bone disease.
Renata C Pereira, Berenice Y Gitomer, Michel Chonchol, Peter C Harris, Kathleen J Noche, Isidro B Salusky, Lauren V Albrecht   +6 more
doaj   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Tolvaptan in Pediatric Autosomal Dominant Polycystic Kidney Disease: From Here to Where?

Kidney Diseases, 2021
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, accounting for approximately 5% of all ESRD cases worldwide.
Fei Liu, Chunyue Feng, Huijun Shen, Huaidong Fu, Jianhua Mao   +4 more
doaj   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source