Results 51 to 60 of about 12,370 (174)
Capillary Endothelia from Two ADPKD Patients are Polyploidy [PDF]
, 2016 Bilateral renal cyst formation is the main feature of autosomal dominant polycystic kidney disease (ADPKD). We and other laboratories have previously shown that cystlining epithelia of kidneys from ADPKD patients are characterized by polyploidy.
AbouAlaiwi, Wissam A. +3 more
core +1 more source
Identification of drug repurposing candidates for the treatment of polycystic kidney disease
British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer +9 more
wiley +1 more source
Fibrosis and progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD) [PDF]
, 2011 The age on onset of decline in renal function and end-stage renal disease (ESRD) in autosomal polycystic kidney disease (ADPKD) is highly variable and there are currently no prognostic tools to identify patients who will progress rapidly to ESRD.
Norman, Jill, Jill Norman
core +1 more source
The Journal of Physiology, Volume 604, Issue 15, Page 6348-6368, 1 August 2026.Abstract figure legend Physiological functions of PKD1, a large transmembrane polycystin protein, are unclear. Previous results obtained using germline non‐specific knockout mice suggested that PKD1 regulates arterial smooth muscle cell contractility.
Angélica K. Bernardelli +7 more
wiley +1 more source
Saudi Journal of Kidney Diseases and Transplantation, 2017 Hypertension is a common early finding in autosomal dominant polycystic kidney disease (ADPKD). Improvements in screening and diagnosis of ADPKD have allowed earlier diagnosis, later onset of end-stage renal disease, and better survival.
Imed Helal +3 more
doaj +1 more source
Amino acid homeostasis in the kidney: Physiological roles and pathological dysregulation
Physiological Reports, Volume 14, Issue 15, August 2026.Abstract Amino acids are fundamental to life as protein building blocks and key regulators of metabolism and signaling. The kidney plays a critical, yet underappreciated, role in amino acid homeostasis through three interconnected pillars: selective glomerular filtration, efficient tubular reabsorption, and metabolic processing, which includes de novo ...
Shuo Liu +3 more
wiley +1 more source
ADPKD: Beyond Growth and Decline [PDF]
, 2017 Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and is characterized by progressive cyst formation in both kidneys and renal function loss. It is the fourth most common cause of end-stage renal disease for
Casteleijn, Niek
core +15 more sources
ADPKD current management and ongoing trials [PDF]
, 2020 Among the diseases that require renal replacement therapy (RRT), ADPKD is the fourth for incidence and prevalence. In Italy, there are at least 32,000 patients affected by ADPKD, of which about 2900 in dialysis.
Magistroni, R., Testa, F.
core +1 more source
Extrarenale Manifestationen der autosomal dominanten polyzystischen Nierenerkrankung (ADPKD) [PDF]
, 2023 Die autosomal dominante polyzystische Nierenerkrankung (ADPKD) ist eine chronisch fortschreitende Systemerkrankung, die bei mehr als 75 % der Betroffenen zu einem Nierenversagen als zentraler Manifestation führt.
Arjune, Sita
core +1 more source
Clinical Case Reports, Volume 14, Issue 7, July 2026.ABSTRACT Methotrexate (MTX) is primarily renally excreted, making patients with end‐stage renal disease (ESRD) highly vulnerable to drug accumulation and toxicity. While severe drug‐induced hypersensitivity syndrome (DIHS) is a known life‐threatening adverse reaction, its association with acute central nervous system complications, specifically ...
Le Mu +6 more
wiley +1 more source