Results 71 to 80 of about 12,370 (174)

HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski, Julia Katharina Scholz, Raluca Ursu, Johannes Schödel, Steffen Grampp, Stephanie Naas, Victoria Lauer, Mario Schiffer, Maike Büttner‐Herold, Bjoern Buchholz, Andre Kraus   +10 more
wiley   +1 more source

Investigating TRPM3 Modulation and Cyst Reversibility in Ex Vivo and Organoid Models of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, affecting approximately 1 in 1000 live births. It is characterised by multiple fluid-filled cysts in renal tubules.
Gul, Huseyin
core   +1 more source

Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Balkan Medical Journal, 2016
Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple, large renal cysts and impaired kidney function. Although the reason for the development of kidney cysts is unknown, ADPKD is associated with cell cycle arrest ...
Funda Sarı, Arzu Didem Yalçın, Gizem Esra Genç, Metin Sarıkaya, Atıl Bisgin, Ramazan Çetinkaya, Saadet Gümüşlü   +6 more
doaj   +1 more source

Polycystin‐1 Controls Cell Cycle Kinetics, Cell Cycle Exit, and Differentiation of Neural Progenitor Cells

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Earlier in neurogenesis, knockdown of polycystin‐1 (PC1) expression increases the cell cycle length of neural progenitor cells (NPCs) by extending the S‐phase and probably lengthening the G1‐phase. Subsequently, reduced PC1 expression causes delayed cell cycle exit and delayed neuronal differentiation of NPCs.
Natalie Winokurow, Stefan Schumacher
wiley   +1 more source

Abdominal Aortic Dissection in a Patient With Autosomal Dominant Polycystic Kidney Disease After Starting Peritoneal Dialysis

Urology Case Reports, 2014
Autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic disorders, is caused by mutations in the PKD1 or PKD2 gene.
Yingying He, Qin Wang, Meng Zhang, Bo Wang, Zuying Xiong, Qiong Luo, Song Wu   +6 more
doaj   +1 more source

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

Urinary Lithogenic Risk Profile in ADPKD Patients Treated with Tolvaptan [PDF]

, 2020
Background and objectives: Nephrolithiasis is a common health problem in autosomal dominant polycystic kidney disease (ADPKD) and significantly contributes to patient morbidity.
Bargagli, Matteo, Mariam Semmo, Fuster, Daniel G., Semmo, Mariam, Matteo Bargagli, Daniel G. Fuster, Anderegg, Manuel, Vogt, Bruno, Uyen Huynh-Do, Ferraro, Pietro Manuel, Huynh-Do, Uyen, Manuel Anderegg, Pietro Manuel Ferraro, Bruno Vogt, Dhayat, Nasser A., Nasser A. Dhayat   +15 more
core   +1 more source

A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models

Disease Models & Mechanisms, 2023
Zhang Li, Kurt A. Zimmerman, Sreelakshmi Cherakara, Phillip H. Chumley, James F. Collawn, Jun Wang, Courtney J. Haycraft, Cheng J. Song, Teresa Chacana, Reagan S. Andersen, Mandy J. Croyle, Ernald J. Aloria, Raksha P. Hombal, Isis N. Thomas, Hanan Chweih, Kristin L. Simanyi, James F. George, John M. Parant, Michal Mrug, Bradley K. Yoder   +19 more
doaj   +1 more source

Autosomal dominant polycystic kidney disease: an overview of recent genetic and clinical advances

Renal Failure
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited kidney disease, characterized by the progressive development of multiple kidney cysts, leading to a gradual decline in kidney function.
Abdul Hamid Borghol, Marie Therese Bou Antoun, Christian Hanna, Mahdi Salih, Frederic F. Rahbari-Oskoui, Fouad T. Chebib   +5 more
doaj   +1 more source

Radiologic and clinical bronchiectasis associated with ADPKD.

, 2014
Top panels (A and B) represent bronchiectasis in a 65 yo ADPKD female with productive cough and dyspnea on exertion, without a known secondary etiology. Panel B delineates enlarged airways visible within 1 cm of the lung periphery. Second panels (C and D)
Ladan Zand (583025), Robert P. Hartman (583026), Teng Moua (544209), Dingxin Qin (583028), Tobias Peikert (544208), Qi Qian (583029), Thomas E. Hartman (583027)   +6 more
core   +1 more source