Results 91 to 100 of about 15,419 (219)

Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand

Balkan Medical Journal, 2016
Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple, large renal cysts and impaired kidney function. Although the reason for the development of kidney cysts is unknown, ADPKD is associated with cell cycle arrest ...
Funda Sarı, Arzu Didem Yalçın, Gizem Esra Genç, Metin Sarıkaya, Atıl Bisgin, Ramazan Çetinkaya, Saadet Gümüşlü   +6 more
doaj   +1 more source

The Alzheimer's Disease Diagnosis and Plasma Phospho‐Tau217 (ADAPT) study stage 1: Validating clinical cut‐points against CSF and amyloid PET

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION We validated plasma phosphorylated tau (p‐tau)217 cut‐points for Alzheimer's disease (AD) diagnosis using two commercial assays in two biomarker‐defined cohorts and examined influences of pre‐analytical factors and chronic kidney disease (CKD) on p‐tau217 concentrations. METHODS Lumipulse (Fujirebio) and ALZpath (Quanterix) assays
Ashvini Keshavan, Katharine Wiltshire, Ryan Wee, Irene Gorostiaga Belio, Katie Tucker, Melanie Hart, Michael P. Lunn, Michael C. B. David, Laura Rizzo, Omid Sadeghi‐Alavijeh, Patricia Wilson, Daniel P. Gale, Amanda J. Heslegrave, Henrik Zetterberg, Nick C. Fox, Paresh Malhotra, Jonathan M. Schott   +16 more
wiley   +1 more source

Autosomal dominant polycystic kidney disease: an overview of recent genetic and clinical advances

Renal Failure
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited kidney disease, characterized by the progressive development of multiple kidney cysts, leading to a gradual decline in kidney function.
Abdul Hamid Borghol, Marie Therese Bou Antoun, Christian Hanna, Mahdi Salih, Frederic F. Rahbari-Oskoui, Fouad T. Chebib   +5 more
doaj   +1 more source

Abdominal Aortic Dissection in a Patient With Autosomal Dominant Polycystic Kidney Disease After Starting Peritoneal Dialysis

Urology Case Reports, 2014
Autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic disorders, is caused by mutations in the PKD1 or PKD2 gene.
Yingying He, Qin Wang, Meng Zhang, Bo Wang, Zuying Xiong, Qiong Luo, Song Wu   +6 more
doaj   +1 more source

A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models

Disease Models & Mechanisms, 2023
Zhang Li, Kurt A. Zimmerman, Sreelakshmi Cherakara, Phillip H. Chumley, James F. Collawn, Jun Wang, Courtney J. Haycraft, Cheng J. Song, Teresa Chacana, Reagan S. Andersen, Mandy J. Croyle, Ernald J. Aloria, Raksha P. Hombal, Isis N. Thomas, Hanan Chweih, Kristin L. Simanyi, James F. George, John M. Parant, Michal Mrug, Bradley K. Yoder   +19 more
doaj   +1 more source

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration, Volume 6, Issue 1, February 2026.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
wiley   +1 more source

Safety and tolerability of autologous bone marrow mesenchymal stromal cells in ADPKD patients

Stem cell research & therapeutics, 2017
BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a genetic ciliopathy disease characterized by progressive formation and enlargement of cysts in multiple organs.
A. Makhlough, Soroosh Shekarchian, R. Moghadasali, B. Einollahi, S. Hosseini, N. Jaroughi, T. Bolurieh, H. Baharvand, N. Aghdami   +8 more
semanticscholar   +1 more source

Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis.

AJP - Renal Physiology, 2018
Research into metabolic reprogramming in cancer has become commonplace, yet this area of research has only recently come of age in nephrology. In light of the parallels between cancer and autosomal dominant polycystic kidney disease (ADPKD), the latter ...
J. Trott, Vicki J. Hwang, T. Ishimaru, K. Chmiel, J. Zhou, K. Shim, B. Stewart, M. Mahjoub, Kuang-Yu Jen, Dinesh K. Barupal, Xiaogang Li, R. Weiss   +11 more
semanticscholar   +1 more source

Generation of a human-induced pluripotent stem cell line (NUMNi003-A) from a patient with autosomal dominant polycystic kidney disease harboring a PKD1 gene variant

Stem Cell Research
PKD1 variants are risk factors for autosomal dominant polycystic kidney disease (ADPKD). However, the detailed mechanisms by which PKD1 variants cause ADPKD remain unclear. Currently, there are no curative treatments for ADPKD.
Akihito Tanaka, Kazuhiro Furuhashi, Asuka Horinouchi, Kumiko Fujieda, Jun Matsumoto, Keita Hattori, Chikao Onogi, Tomohiro Kawazoe, Akihisa Kato, Yu Watanabe, Eri Koshi-Ito, Noritoshi Kato, Itaru Kushima, Norio Ozaki, Shoichi Maruyama   +14 more
doaj   +1 more source

Reduction in Heart Rate Variability in Autosomal Dominant Polycystic Kidney Disease

Kidney & Blood Pressure Research, 2019
Introduction: Cardiovascular disease is one of the main causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD).
Silvia Lai, Marco Mangiulli, Adolfo M. Perrotta, Gianluca Di Lazzaro Giraldi, Massimo Testorio, Edoardo Rosato, Rosario Cianci, Antonietta Gigante   +7 more
doaj   +1 more source