Results 91 to 100 of about 12,370 (174)

Generation of an induced pluripotent stem cell line (ZSPHARi002-A) from a patient with autosomal dominant polycystic kidney disease carrying a heterozygous PKD1 mutation

Stem Cell Research
Autosomal dominant polycystic kidney disease (ADPKD), a single-gene-inherited kidney disease, is a common cause of end-stage kidney disease (ESKD). The PKD1 gene mutation is the most common cause of ADPKD, accounting for approximately 78% of cases. ADPKD
Yeye Zhang, Ye Chen, Jun Fan, Guangzhao Lu, Qianzhou Lv, Donghui Lao, Xiaoyu Li   +6 more
doaj   +1 more source

Clinical outcomes, quality of life, and therapeutic management in patients with ADPKD: a retrospective single-center observational study

reservedABSTRACT Background: la malattia del rene policistico autosomico dominante (ADPKD) è una nefropatia ereditaria caratterizzata dalla progressiva formazione di cisti renali con declino della funzione renale. Il tolvaptan, antagonista selettivo del
MARTINETTI, LORIS
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The Relationship of Renalase with Diurnal Blood Pressure Rhythm, Left Ventricular Mass Index and Carotid Intima–media Thickness in Autosomal Dominant Polycystic Kidney Disease

Saudi Journal of Kidney Diseases and Transplantation
This study investigated the relationship between renalase and diurnal blood pressure (BP) rhythm, left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) in autosomal dominant polycstic kidney disease (ADPKD) patients.
Veysel Erol, Mevlüt Çeri, Mehmet Mert, Oğuz Kılıç, İsmail Doğu Kılıç, İbrahim Hasbey, Nuran Sabır, Süleyman Demir, Ayşen Kardeşler, Belda Dursun   +9 more
doaj   +1 more source

Water channel expression in human ADPKD kidneys

, 1995
Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) results in part from the transport of solute and fluid into the lumen of the cyst.
D. Brown, D. S. Emmanouel, D. M. Jefferson, F. A. Carone, I. Sabolic, D. R. Bachinsky, R. D. Perrone   +6 more
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Patient-Reported Outcomes Measures, Polycystic Kidney Disease Burden, and Outcomes in Autosomal Dominant Polycystic Kidney Disease

Kidney Medicine
Rationale & Objective: Using OVERTURE (NCT01430494) study data on patient-perceived health, health care utilization, and productivity in autosomal dominant polycystic kidney disease (ADPKD), this research was conducted to characterize the burden of ...
Dorothee Oberdhan, Aaron Yarlas, Jakob B. Bjorner, Holly Krasa   +3 more
doaj   +1 more source

Kidney Volume and Molecular Processes are Dynamic in ADPKD

Kidney International Reports
Introduction: Although progress has been made toward elucidating cellular pathways related to initial cystogenesis in autosomal dominant polycystic kidney disease (ADPKD), the mechanisms that contribute to disease progression and the timing of ...
Ali Tug, Jamie Zheng, Yahya Alsawaf, Jared Lutsic, Athreya Rangavajhula, Nalin Sharma, Youwen Zhang, Ivan Vuckovic, Slobodan Macura, Christian Hanna, Marie C. Hogan, Vicente E. Torres, Peter C. Harris, Alfonso Eirin, Maria V. Irazabal   +14 more
doaj   +1 more source

End-stage renal disease in autosomal dominant polycystic kidney disease: a comparison of dialysis-related utilization and costs with other chronic kidney diseases

ClinicoEconomics and Outcomes Research, 2015
Steven M Brunelli,1 Christopher M Blanchette,2,3 Ami J Claxton,1 Debosree Roy,2 Sandro Rossetti,3 Benjamin Gutierrez31DaVita Clinical Research, Minneapolis, MN, USA; 2University of North Carolina, Charlotte, NC, USA; 3Otsuka America Pharmaceutical, Inc.,
Brunelli SM, Blanchette CM, Claxton AJ, Roy D, Rossetti S, Gutierrez B   +5 more
doaj  

Applicability of Mayo’s Autosomal Dominant Polycystic Kidney Disease (ADPKD) Prognostic Tool in the Southeast Asian ADPKD Population

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterised by progressive cyst growth leading to loss of kidney function.
Soo Kun Lim, Wai Ling Leong, Jun Min Em, En Thong Goh, Chye Chung Gan, Jing Qin Tay, Soo Ying Yew, Shok Hoon Ooi, Anushya Vijayananthan, Peng Loon Cheah   +9 more
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End Point Selection in ADPKD Clinical Trials

Kidney International Reports
Autosomal dominant polycystic kidney disease (ADPKD) is the leading hereditary cause of kidney failure. Challenges have arisen in developing consensus-based clinical trial end points endorsed by the wider ADPKD research community and regulators.
Kitty St Pierre, Ragada El-Damanawi, Julia Jefferis, David W. Johnson, Carmel M. Hawley, Christine E. Staatz, Andrea K. Viecelli, Andrew J. Mallett   +7 more
doaj   +1 more source

[Molecular diagnosis of ADPKD]

, 2016
Most patients with ADPKD do not need molecular genetic testing. When indicated, Sanger sequencing is the most commonly used technique. When a pathogenic mutation is not identified by Sanger, multiplex ligation-dependent probe amplification analysis (MLPA)
SCOLARI, Francesco, Savoldi, Gianfranco, Mazza, Cinzia, Izzi, Claudia   +3 more
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