Results 111 to 120 of about 15,419 (219)

Generation of an induced pluripotent stem cell line (ZSPHARi002-A) from a patient with autosomal dominant polycystic kidney disease carrying a heterozygous PKD1 mutation

Stem Cell Research
Autosomal dominant polycystic kidney disease (ADPKD), a single-gene-inherited kidney disease, is a common cause of end-stage kidney disease (ESKD). The PKD1 gene mutation is the most common cause of ADPKD, accounting for approximately 78% of cases. ADPKD
Yeye Zhang, Ye Chen, Jun Fan, Guangzhao Lu, Qianzhou Lv, Donghui Lao, Xiaoyu Li   +6 more
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The Relationship of Renalase with Diurnal Blood Pressure Rhythm, Left Ventricular Mass Index and Carotid Intima–media Thickness in Autosomal Dominant Polycystic Kidney Disease

Saudi Journal of Kidney Diseases and Transplantation
This study investigated the relationship between renalase and diurnal blood pressure (BP) rhythm, left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) in autosomal dominant polycstic kidney disease (ADPKD) patients.
Veysel Erol, Mevlüt Çeri, Mehmet Mert, Oğuz Kılıç, İsmail Doğu Kılıç, İbrahim Hasbey, Nuran Sabır, Süleyman Demir, Ayşen Kardeşler, Belda Dursun   +9 more
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End Point Selection in ADPKD Clinical Trials

Kidney International Reports
Autosomal dominant polycystic kidney disease (ADPKD) is the leading hereditary cause of kidney failure. Challenges have arisen in developing consensus-based clinical trial end points endorsed by the wider ADPKD research community and regulators.
Kitty St Pierre, Ragada El-Damanawi, Julia Jefferis, David W. Johnson, Carmel M. Hawley, Christine E. Staatz, Andrea K. Viecelli, Andrew J. Mallett   +7 more
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End-stage renal disease in autosomal dominant polycystic kidney disease: a comparison of dialysis-related utilization and costs with other chronic kidney diseases

ClinicoEconomics and Outcomes Research, 2015
Steven M Brunelli,1 Christopher M Blanchette,2,3 Ami J Claxton,1 Debosree Roy,2 Sandro Rossetti,3 Benjamin Gutierrez31DaVita Clinical Research, Minneapolis, MN, USA; 2University of North Carolina, Charlotte, NC, USA; 3Otsuka America Pharmaceutical, Inc.,
Brunelli SM, Blanchette CM, Claxton AJ, Roy D, Rossetti S, Gutierrez B   +5 more
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ADPKD

, 2019
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inheritable kidney disease. It is characterized by progressive kidney cyst formation throughout life, which can lead to kidney failure. However, only 70% of patients will develop kidney failure and the age at which patients develop kidney failure shows a large interindividual ...
openaire   +1 more source

Patient-Reported Outcomes Measures, Polycystic Kidney Disease Burden, and Outcomes in Autosomal Dominant Polycystic Kidney Disease

Kidney Medicine
Rationale & Objective: Using OVERTURE (NCT01430494) study data on patient-perceived health, health care utilization, and productivity in autosomal dominant polycystic kidney disease (ADPKD), this research was conducted to characterize the burden of ...
Dorothee Oberdhan, Aaron Yarlas, Jakob B. Bjorner, Holly Krasa   +3 more
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ADPKD

, 2017
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and is characterized by progressive cyst formation in both kidneys and renal function loss. It is the fourth most common cause of end-stage renal disease for which renal replacement therapy has to be started.
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Kidney Volume and Molecular Processes are Dynamic in ADPKD

Kidney International Reports
Introduction: Although progress has been made toward elucidating cellular pathways related to initial cystogenesis in autosomal dominant polycystic kidney disease (ADPKD), the mechanisms that contribute to disease progression and the timing of ...
Ali Tug, Jamie Zheng, Yahya Alsawaf, Jared Lutsic, Athreya Rangavajhula, Nalin Sharma, Youwen Zhang, Ivan Vuckovic, Slobodan Macura, Christian Hanna, Marie C. Hogan, Vicente E. Torres, Peter C. Harris, Alfonso Eirin, Maria V. Irazabal   +14 more
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SGLT2 Inhibitors in ADPKD

Journal of the American Society of Nephrology
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder and a leading cause of kidney failure worldwide. Disease progression is driven by cyst expansion, tubular injury, and maladaptive metabolic and hemodynamic changes.
Marie Therese Bou Antoun, Abdul Hamid Borghol, Levon Souvalian, Mohamad Hadla, Georges Abboud, Ahmad Ghanem, Fadi George Munairdjy Debeh, Jean Marc Mardirossian, Mahdi Salih, Pranav S. Garimella, Volker Vallon, Fouad T. Chebib   +11 more
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Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease

Turkish Journal of Nephrology, 2019
OBJECTIVE: Early arterial stiffness has been shown in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function. However, to our knowledge, no prospective study evaluated changes in arterial functions in patients with ...
Abdülmecit YILDIZ, Alparslan ERSOY, Saim SAĞ, Ayşegül ORUÇ, Ercan ÇİĞİLLİ, Yavuz AYAR, Sümeyye GÜLLÜLÜ, Cuma Bülent GÜL   +7 more
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