Results 201 to 210 of about 552,750 (375)

Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis. [PDF]

Ren Fail
Lian Z, Liang Z, Chen Q, Xie C, Kong Y.
europepmc   +1 more source

Costs and Benefits of Prenatal Screening For Cystic Fibrosis [PDF]

Newly-developed genetic tests based on restriction fragment length polymorphisms (RFLPs) promise to facilitate the early detection of genetic diseases. Several such tests are now available for the prenatal detection of cystic fibrosis (CF), a common and ...
Alan M. Garber, Joseph P. Fenerty
core  

A Phase I, First‐In‐Human Study of CBA‐1205, an Anti‐DLK1 Monoclonal Antibody, in Patients With Advanced Solid Tumors

Cancer Science, Volume 116, Issue 4, Page 1012-1022, April 2025.
We conducted a Phase I trial of CBA‐1205, a novel monoclonal antibody targeting DLK1, in advanced solid tumors, demonstrating safety and tolerability with no dose‐limiting toxicities. Preliminary efficacy was observed, with six patients achieving stable disease for over 6 months, and sDLK1 was identified as a potential biomarker associated with ...
Yuki Katsuya, Masafumi Ikeda, Takafumi Koyama, Jun Sato, Mao Okada, Nobuaki Matsubara, Chihiro Kondoh, Toru Mukohara, Kazuo Watanabe, Daisuke Kotani, Yoshimi Ogawa, Shose Taoka, Noboru Yamamoto   +12 more
wiley   +1 more source

The spectrum of diseases, genetic landscape and new mutation sites of hereditary cystic kidney disease. [PDF]

Clin Kidney J
Bi J, Guo W, Ji P, Li S, Wang P, Li Q, Xie Y.   +6 more
europepmc   +1 more source

A Rare Diagnosis of Caroli Syndrome in a Young Patient [PDF]

Clin Case Rep
ABSTRACT Caroli syndrome is a rare but serious congenital disorder associated with portal hypertension and polycystic kidney disease. Early diagnosis via imaging, particularly MRCP, is crucial to prevent life‐threatening complications such as cholangitis and biliary cirrhosis.
Karimzadeh‐Soureshjani E, Pourhasan F, Simab P, Shojaei S, Mohammadian Y.   +4 more
europepmc   +2 more sources

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, EarlyView.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

Imaging Diagnosis-Sonographic Features of Bilateral Renal Lymphangiectasia in an Azotemic Dog. [PDF]

Vet Radiol Ultrasound
Wang Y, Mai W, Dourmashkin L, Leopardi V, Amerman H.   +4 more
europepmc   +1 more source

Safety and effectiveness of fingolimod in Japanese patients with multiple sclerosis: Results of a post‐marketing surveillance study

Clinical and Experimental Neuroimmunology, Volume 16, Issue 2, Page 118-131, May 2025.
Abstract Objective Fingolimod is the first oral sphingosine‐1‐phosphate receptor modulator approved in Japan for multiple sclerosis (MS). A large Japanese observational study of fingolimod in patients with MS was carried out to support its safety and effectiveness in a real‐world setting.
Noriko Sato, Koji Wakimoto, Kyoko Kato, Yutaka Susuta, Kengo Ueda, Yoshihisa Satou, Takayoshi Sasajima, Jun‐ichi Kira   +7 more
wiley   +1 more source

Renal fibrosis is the common feature of autosomal dominant tubulointerstitial kidney diseases caused by mutations in mucin 1 or uromodulin.

Kidney International, 2014
A. Ekici, Thomas Hackenbeck, V. Moriniére, Andrea Pannes, M. Buettner, S. Uebe, R. Janka, Antje Wiesener, I. Hermann, S. Grupp, M. Hornberger, T. Huber, N. Isbel, G. Mangos, S. McGinn, Daniela Soreth-Rieke, B. Beck, M. Uder, K. Amann, C. Antignac, A. Reis, K. Eckardt, M. Wiesener   +22 more
semanticscholar   +1 more source

Extrarenal Clinical Features are Reported for Most Genes Implicated in Genetic Kidney Disease. [PDF]

Kidney Int Rep
Serrano B, Savige J.
europepmc   +1 more source