Results 191 to 200 of about 617,774 (332)

Use of prostanoid receptors as a therapeutic target for polycystic kidney diseases

open access: yes
Background: Beyond tolvaptan, there are no other therapies for polycystic kidney diseases (PKD), a class of inherited cystic kidney diseases. Many of the PKD-inducing mutations translate into changes in cyclic AMP (cAMP) signaling, which is understood to
Sidhu, Karanbir
core  

An update on the landscape of collagen bioactive fragments

open access: yesThe FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Diagnostic Yield and Clinical Utility of Genetic Testing in Turkish Adults with Suspected Inherited Kidney Disease: Insights from a Population with High Parental Consanguinity. [PDF]

open access: yesJ Clin Pract Res
Kumru G   +14 more
europepmc   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

open access: yesThe FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin   +2 more
wiley   +1 more source

Updates and controversies in contemporary grading of clear cell renal cell carcinoma and papillary renal cell carcinoma

open access: yesHistopathology, EarlyView.
New concepts, innovations and some issues have emerged since the adoption a decade ago of WHO/ISUP grading for CCRCC and PRCC. Continued use of the WHO/ISUP grading for CCRCC and PRCC has been upheld by newer studies, and practice guidance for some of the grading issues, where data are available, is provided.
Gladell P. Paner   +4 more
wiley   +1 more source

Back‐up arteriovenous fistula in peritoneal dialysis patients: a retrospective cohort study of long‐term meaningful outcomes

open access: yesInternal Medicine Journal, EarlyView.
ABSTRACT Background Back‐up arteriovenous fistula (bAVF) is used in peritoneal dialysis (PD) to avoid haemodialysis transfer via a central venous catheter (CVC). However, no previous study examined mortality or complications associated with bAVF creation.
Hicham I. Cheikh Hassan   +3 more
wiley   +1 more source

Adult and pediatric cystic nephroma: an easily misdiagnosed renal tumor. [PDF]

open access: yesFront Oncol
Zi GR   +5 more
europepmc   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

open access: yesJournal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi   +4 more
wiley   +1 more source

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