Results 41 to 50 of about 645,542 (342)

Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia [PDF]

, 1976
In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there
Hansbrough, JF, Hoelscher, M, Porter, KA, Putnam, CW, Schröter, GPJ, Starzl, TE   +5 more
core   +1 more source

Acquired cystic kidney disease

Kidney International, 1991
A 34-year-old black sales manager was referred for evaluation of azotemia of undetermined duration. He claimed to be in good health except for "borderline" hypertension since age 25. He had no history of urinary tract signs or symptoms. A tumor of unspecified type had been removed from the left anterior chest wall 8 years previously; there had been no ...
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression

EMBO Molecular Medicine
Polycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained in vitro by the enzyme ...
Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana SH Costa, Antonio Esposito, Angelo D’Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta   +16 more
doaj   +1 more source

Acquired cystic disease and renal cell carcinoma in hemodialysis patients: A case report on three patients [PDF]

Vojnosanitetski Pregled, 2015
Introduction. Renal cell carcinoma (RCC) is derived from renal tubular epithelial cells and represents approximately 3.8% of all malignancies in adults. The incidence of renal cell carcinoma has been growing steadily and ranging from 0.6 to 14.7
Mijušković Mirjana, Milović Novak, Kovačević Božidar, Jovanović Dragan, Stefanović Dara, Ignjatović Ljiljana, Terzić Brankica, Tadić-Pilčević Jelena, Petrović Marijana, Pilčević Dejan, Obrenčević Katarina, Cerović Snežana   +11 more
doaj   +1 more source

The association of preoperative cardiac stress testing with 30-day death and myocardial infarction among patients undergoing kidney transplantation [PDF]

, 2019
BACKGROUND:Although periodic cardiac stress testing is commonly used to screen patients on the waiting list for kidney transplantation for ischemic heart disease, there is little evidence to support this practice.
Alhamad, Tarek, Brown, David L, Dunn, Tim, Novak, Eric, Rich, Michael W, Saeed, Mohammed J, Shpigel, Adam, Stwalley, Dustin   +7 more
core   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Primary URECs: a source to better understand the pathology of renal tubular epithelia in pediatric hereditary cystic kidney diseases

Orphanet Journal of Rare Diseases, 2022
Background In pediatric hereditary cystic kidney diseases, epithelial cell defects mostly result from rare, autosomal recessively inherited pathogenic variants in genes encoding proteins of the cilia-centrosome complex.
Wolfgang H. Ziegler, Sarah Lüdiger, Fatima Hassan, Margarita E. Georgiadis, Kathrin Swolana, Amrit Khera, Arne Mertens, Doris Franke, Kai Wohlgemuth, Mareike Dahmer-Heath, Jens König, Claudia Dafinger, Max C. Liebau, Metin Cetiner, Carsten Bergmann, Birga Soetje, Dieter Haffner   +16 more
doaj   +1 more source

Contrast-enhanced ultrasound examination for the assessment of renal perfusion in cats with chronic kidney disease [PDF]

, 2017
Background: Contrast-enhanced ultrasound examination (CEUS) is a functional imaging technique allowing noninvasive assessment of tissue perfusion. Studies in humans show that the technique holds great potential to be used in the diagnosis of chronic ...
Daminet, Sylvie, Duchateau, Luc, Paepe, Dominique, Saunders, Jimmy, Stock, Emmelie, Vandermeulen, Eva, Vanderperren, Katrien   +6 more
core   +2 more sources