Results 261 to 270 of about 857,514 (313)

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Glucagon-like peptide-1 receptor agonists, inflammation, and kidney diseases: evidence from Mendelian randomization. [PDF]

Ren Fail
Yao YX, Tang C, Si FL, Lv JC, Shi SF, Zhou XJ, Liu LJ, Zhang H.   +7 more
europepmc   +1 more source

Non‐Invasive Diagnosis of Chronic Myocardial Infarction via Composite In‐Silico‐Human Data Learning

Advanced Science, EarlyView.
This study presents a non‐invasive machine learning model to identify infarct regions in the left ventricle using cardiac strain data. By combining rodent‐based simulated data with limited human data, the model achieves high accuracy in predicting infarct size and location without the need for gadolinium contrast agents, offering a promising ...
Rana Raza Mehdi, Nikhil Kadivar, Tanmay Mukherjee, Emilio A. Mendiola, Akila Bersali, Dipan J. Shah, George Karniadakis, Reza Avazmohammadi   +7 more
wiley   +1 more source

PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases. [PDF]

Sci Adv
Fang X, Zhong Y, Zheng R, Wu Q, Liu Y, Zhang D, Wang Y, Ding W, Wang K, Zhong F, Lin K, Yao X, Hu Q, Li X, Xu G, Liu N, Nie J, Li D, Geng H, Guan Y.   +19 more
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

The spatiotemporal and paradoxical roles of NRF2 in renal toxicity and kidney diseases. [PDF]

Redox Biol
Bian Y, Dong J, Zhou Z, Zhou H, Xu Y, Zhang Q, Chen C, Pi J.   +7 more
europepmc   +1 more source

Relation equivariant graph neural networks to explore the mosaic-like tissue architecture of kidney diseases on spatially resolved transcriptomics. [PDF]

Bioinformatics
Raina M, Cheng H, Ferreira RM, Stansfield T, Modak C, Cheng YH, Suryadevara HNSK, Xu D, Eadon MT, Ma Q, Wang J.   +10 more
europepmc   +1 more source

The association of RBP4 with chronic kidney diseases in southern Chinese population. [PDF]

Front Endocrinol (Lausanne)
Chen T, Liu Y, Wu S, Long S, Feng L, Lu W, Chen W, Hong G, Zhou L, Wang F, Luo Y, Zou H, Liu W.   +12 more
europepmc   +1 more source

Unveiling the therapeutic potential of berberine: its therapeutic role and molecular mechanisms in kidney diseases. [PDF]

Front Pharmacol
Fan Z, Wei X, Zhu X, Yang K, Tian L, Wang X, Du Y, Yang L.   +7 more
europepmc   +1 more source

Editorial: Hold the salt: dietary sodium's effect on cardiovascular and kidney diseases. [PDF]

Front Nutr
Baldo MP, Serrano MDC, Pitzer Mutchler A, Lee Y.   +3 more
europepmc   +1 more source