Results 191 to 200 of about 445,898 (264)

BRASH Syndrome. [PDF]

Clin Case Rep
Iyow SN, Adam AM, Adan HAA, Sağdıç A, Mohamed AY.   +4 more
europepmc   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Wild-Type Transthyretin Cardiac Amyloidosis Presenting As Progressive Heart Failure and Conduction Disease Despite Guideline-Directed Medical Therapy. [PDF]

Cureus
Richard S, Thomas D, Gorantla A, Devkota S, Graham-Hill S.   +4 more
europepmc   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular-Kidney-Metabolic Syndrome. [PDF]

Diabetes Obes Metab
Zeitler E, Klein KR, Lingvay I, Pick A, Billings LK.   +4 more
europepmc   +1 more source

Living Donor Liver Transplantation in Patients with or Without Acute-on-Chronic Liver Failure: A Single Center Experience. [PDF]

J Clin Med
Aljudaibi B, Alshehri L, Almudaiheem B, Mirza S, Mirza A, Danish A, Qazi MH, Shoaib M, Hamed Y, Malago M, Raptis D, Alabbad S, Saner F, Alghamdi S, Alfhaid A, Abufarhaneh E, Alqahtani S, Broering D, Bzeizi K.   +18 more
europepmc   +1 more source

Predictors of Long-Term Kidney Transplant Survival: A Scoping Review. [PDF]

Health Sci Rep
Toni E, Ayatollahi H, Ziyaee S, Rahimi F.   +3 more
europepmc   +1 more source

Management Strategies for Congestive Heart Failure in Chronic Kidney Disease: Narrative Review. [PDF]

Biomedicines
Soto-Santillan P, Jacobo-Ruvalcaba A, Wasung-de Lay ME, Orihuela-Rodriguez O.   +3 more
europepmc   +1 more source

Multidimensional toxicity of snake venom causes multi-organ damage and treatment challenges: a narrative review. [PDF]

Front Pharmacol
Tong D, Chen L, Xu J.
europepmc   +1 more source