Results 221 to 230 of about 4,209,711 (302)

Development and validation of an interpretable machine learning model for early prediction of mortality in ICU patients with chronic obstructive pulmonary disease and heart failure. [PDF]

Medicine (Baltimore)
Shen J, Liu Y, Chen Y.
europepmc   +1 more source

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

Advanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li, Rui Fan, Kun Xie, Jiehua Zhong, Yitong Zhu, Tingting Ji, Yuanyuan Qin, Shijin Peng, Yu Zhang, Yuhang Guo, Tiange Zhang, Chunchen Liu, Bo Li, Lei Zheng, Ye Zhang, Xiaohui Yan   +15 more
wiley   +1 more source

Cardiorenal Syndrome: Pathophysiology, Management, and the Challenge of Therapeutic Inertia. [PDF]

Medicina (Kaunas)
Gembillo G, Calabrese V, Soraci L, Lo Cicero L, Scapellato M, Messina R, Ricca MF, Stancanelli MR, Corsonello A, Santoro D.   +9 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Investigation of Torque Teno Virus Loads as a Marker of Immunosuppression in Pediatric Chronic Renal Failure: A Pilot Study. [PDF]

Pediatr Transplant
Kelly E, Awan A, Wildes D, De Gascun CF, Drew RJ, Heggenstaller A, Riordan M, Hassan J.   +7 more
europepmc   +1 more source

<i>Clostridioides difficile</i> Infection in a Romanian Tertiary Care Hospital: Epidemiology, Comorbidity Burden, Treatment Patterns, and Mortality Outcomes (2023-2025). [PDF]

Antibiotics (Basel)
Vlad T, Vlad DC, Muntean C, Flangea C, Dumitrașcu V, Popescu R, Mitulețu M, Vlad CS.   +7 more
europepmc   +1 more source

Smoking exposure and long-term progression of IgA nephropathy: a retrospective cohort study of 9,560 patients. [PDF]

Ren Fail
Le WB, Shi JS, Liu F, Cheng Z.
europepmc   +1 more source