Results 101 to 110 of about 5,063,263 (354)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The modern spectrum of biopsy-proven renal disease in Chinese diabetic patients—a retrospective descriptive study [PDF]

PeerJ, 2018
Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking.
Diankun Liu, Ting Huang, Nan Chen, Gang Xu, Ping Zhang, Yang Luo, Yongping Wang, Tao Lu, Long Wang, Mengqi Xiong, Jian Geng, Sheng Nie   +11 more
doaj   +2 more sources

Francisella tularensis Transmission by Solid Organ Transplantation, 20171. [PDF]

, 2019
In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died.
Annambhotla, Pallavi, Asad, Shadaba, Aslam, Saima, Basavaraju, Sridhar V, Brown, Jennifer, Burns, Kevin, Carifo, Karen, Dagher, Hikmat N, Fritz, Curtis L, Gonzalez, Anthony, Ham, John, Helsel, Elizabeth, Hinckley, Alison F, Iser, Joseph, Johnson, Michael, Jones, Jefferson M, Kelley, Walter E, Kingry, Luke C, Krafft, Melissa, Kwit, Natalie A, Medina-Garcia, Luis H, Mohler, Kelli, Murua, Christian, Nelson, Christina A, Petersen, Jeannine M, Respicio-Kingry, Laurel, Tularemia in Transplant Recipients Investigation Team, Wiggins, Landon, Zhang, Ying   +28 more
core  

A cohort study on the rate of progression of diabetic chronic kidney disease in different ethnic groups. [PDF]

, 2013
OBJECTIVE: To compare the rate of progression of diabetic chronic kidney disease in different ethnic groups. DESIGN: Prospective longitudinal observational study. PARTICIPANTS: All new patients attending a tertiary renal unit in east London with diabetic
Ali, O, Dreyer, G, Hull, S, Mathur, R, Mohiuddin, A, Yaqoob, MM   +5 more
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

International consensus definitions of clinical trial outcomes for kidney failure: 2020.

Kidney International, 2020
Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems, payers, and regulators. However, no harmonized international consensus definitions of kidney failure and key surrogates of progression to kidney failure ...
A. Levin, R. Agarwal, W. Herrington, H. Heerspink, J. Mann, S. Shahinfar, Katherine R. Tuttle, Jo-Ann Donner, V. Jha, M. Nangaku, D. de Zeeuw, M. Jardine, K. Mahaffey, A. Thompson, M. Beaucage, Kate Chong, Glenda V Roberts, Duane Sunwold, H. Vorster, Madeleine Warren, S. Damster, Charu Malik, V. Perkovic   +22 more
semanticscholar   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Sirtuin 6 is a key contributor to gender differences in acute kidney injury

Cell Death Discovery, 2023
Acute kidney injury (AKI) is rapidly increasing nowadays and at a high risk to progress into chronic kidney disease (CKD). Of note, men are more susceptive to AKI, suggesting gender differences in AKI patients.
Jinhua Miao, Jiewu Huang, Ye Liang, Yunfang Zhang, Jiemei Li, Ping Meng, Weiwei Shen, Xiaolong Li, Qinyu Wu, Xiaoxu Wang, Hongxin Niu, Ying Tang, Shan Zhou, Lili Zhou   +13 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis

Cell Death and Disease, 2023
Keratinocyte hyperproliferation is a key pathogenic factor in psoriasis. However, the mechanisms that regulate keratinocyte hyperproliferation in this condition remain unclear. Here, we found that SLC35E1 was highly expressed in keratinocytes of patients
Tao Huang, Shijun Chen, Ke Ding, Baoqing Zheng, Weiqi Lv, Xiaobo Wang, Yadan Zhong, Hongxin Huang, Xin Zhang, Shufeng Ma, Bin Yang, Xiaohua Wang, Zhili Rong   +12 more
doaj   +1 more source