Results 91 to 100 of about 687,778 (313)

Risk of postoperative acute kidney injury in patients undergoing orthopaedic surgery—development and validation of a risk score and effect of acute kidney injury on survival:observational cohort study [PDF]

, 2015
Objective: To develop and externally validate a risk score to predict post-operative Acute Kidney Injury (AKI) in patients undergoing orthopaedic surgery and to examine the impact of AKI on both short and long term survival.
Deshmukh, Harshal, Vadiveloo, T, Bell, S, Vadiveloo, Thenmalar, Bell, S., Deshmukh, H., Donnan, P.T., Deshmukh, H, Van, Diepen M, Dekker, F.W., Marwick, C., Van Diepen, Merel, Dekker, Friedo W., Diepen, M. van, Donnan, PT, Bell, Samira; id_orcid, Marwick, C, Marwick, Charis; id_orcid, Dekker, FW, Vadiveloo, T., Donnan, Peter T.; id_orcid   +20 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis

Journal of Extracellular Vesicles, 2022
Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD), suggesting intimate communication between the two types of cells. However, the underlying mechanisms remain to be determined.
Shuangqin Chen, Meijia Zhang, Jiemei Li, Jiewu Huang, Shan Zhou, Xiaotao Hou, Huiyun Ye, Xi Liu, Shaowei Xiang, Weiwei Shen, Jinhua Miao, Fan Fan Hou, Youhua Liu, Lili Zhou   +13 more
doaj   +1 more source

Respiratory failure: A rare complication of chronic kidney disease mineral and bone disorder

, 2019
Background: Disordered metabolism of bone and minerals is a problem frequently encountered in patients with chronic kidney disease. Early biochemical changes include altered calcium and phosphate balance, while advanced disease produces reduced bone ...
Yaxley, J, Scott, T
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Myogenic constriction in renal failure : cause and therapy [PDF]

, 2012
In bloeddruk regulerende vaten, de zogenaamde weerstandsvaten, wordt myogene constrictie geactiveerd door verhoogde transmurale druk. De verhoogde transmurale druk zorgt voor contractie van het arteriële gladde spierweefsel, met vernauwing van het lumen ...
Vavrinec, Peter,, Vavrinec, Peter
core  

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Re: Timing of Pregnancy after Kidney Transplantation and Risk of Allograft Failure

, 2016
The authors have investigated the risk of allograft failure due to the timing of pregnancy after kidney transplantation. Of the 21.814 women aged 15-45 who have received a first kidney-only transplant in the United States Renal Data System, 729 ...
Serkan Akıncı
core   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Biomarkers of Kidney Failure and All-Cause Mortality in CKD [PDF]

Key Points Established risk factor models demonstrate excellent discrimination for CKD outcomes but do not adequately reflect disease activity or mechanisms.We have developed models solely from novel biomarkers that reflect key disease pathways driving ...
Skroblin, Phillipp, Lemaître, Barbara, Onoja, Anthony, Fraser, Simon DS, Unwin, Robert J, Wheeler, David C, McDonnell, Thomas, Skroblin, Philipp, Fraser, Simon D S, Kalra, Philip A, Bergin, Marianne, Taal, Maarten W., Vuilleumier, Nicolas, Fraser, Simon D.S., Unwin, Robert J., Johnson, Tim, Banks, Rosamonde E, Annessi, Isabelle, Kalra, Philip A., Cockwell, Paul, Dusaulcy, Rodolphe, Taal, Maarten W, Soderberg, Magnus, Saleem, Moin, Banks, Rosamonde E., Annessi Ramseyer, Isabelle, Wheeler, David C., Geifman, Nophar   +27 more
core   +1 more source