Results 91 to 100 of about 5,063,263 (354)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Acute kidney injury in the elderly: predisposition to chronic kidney disease and vice versa. [PDF]

, 2011
There have been considerable advances in the past few years in our understanding of how chronic kidney disease (CKD) predisposes to acute kidney injury (AKI) and vice versa.
Cho, Kerry C, Coca, Steven G, Hsu, Chi-yuan   +2 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Association of iron deficiency with kidney outcome and all-cause mortality in chronic kidney disease patients without anemia

Nutrition Journal
Background Iron deficiency is prevalent in patients with chronic kidney disease (CKD), even in those without anemia. However, the effects of iron deficiency on CKD progression and all-cause mortality in non-dialysis-dependent CKD (NDD-CKD) patients ...
Hongxue Yu, Xian Shao, Zhixin Guo, Mingzhen Pang, Shan Chen, Caoxiang She, Lisha Cao, Fan Luo, Ruixuan Chen, Shiyu Zhou, Xin Xu, Sheng Nie   +11 more
doaj   +1 more source

Urinary Neutrophil Gelatinase-associated Lipocalin as a Marker for Identification of Acute Kidney Injury and Recovery in Dogs with Gentamicin-induced Nephrotoxicity. [PDF]

, 2016
BackgroundAcute kidney injury (AKI) is associated with high mortality rates in dogs, which may be a consequence of late recognition using traditional diagnostic tests.
Cowgill, LD, Kanakubo, K, Kowalkowski, KL, LeRoy, BE, Palm, CA, Segev, G, Westropp, JL   +6 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

U-shaped association between triglyceride-glucose index and all-cause mortality among critically ill pediatrics: a population-based retrospective cohort study

Cardiovascular Diabetology
Background Previous studies have shown that an elevated triglyceride-glucose (TyG) index was associated with all-cause mortality in both general adult individuals and critically ill adult patients.
Qi Gao, Fan Luo, Hongxue Yu, Yuxin Lin, Ruqi Xu, Pingping Li, Yuping Zhang, Jiao Liu, Licong Su, Yanqin Li   +9 more
doaj   +1 more source

Association Between New-Onset Proteinuria During Hospitalization and Cardiovascular Mortality Among Patients With Atherosclerotic Cardiovascular Disease

JACC: Advances
Background: Evidence regarding the prognostic value of new-onset proteinuria during hospitalization among patients with atherosclerotic cardiovascular disease (ASCVD) is lacking.
Licong Su, MD, Ruixuan Chen, MD, Shiyu Zhou, MD, Zhixin Guo, MS, Yanqin Li, MD, Xiaodong Zhang, MD, Fan Luo, MD, Qi Gao, MD, Yuxin Lin, MD, Lisha Cao, MS, Jiao Liu, MS, Mingzhen Pang, MD, Caoxiang She, MS, Xin Xu, MD, Sheng Nie, MD   +14 more
doaj   +1 more source

Renal and Hepatic Dysfunction in Malaria Patients in Minna, North Central Nigeria [PDF]

, 2009
Information on kidney and liver involvement in malaria in Africa is still very scanty. Kidney and liver functions were assessed in 70 malaria patients using serum levels of creatinine and urea and urinary protein levels as test indicators of kidney ...
Ogbadoyi, EO, Tsado, RD
core   +1 more source

Prognostic robustness of serum creatinine based AKI definitions in patients with sepsis: a prospective cohort study [PDF]

, 2015
Background: It is unclear how modifications in the way to calculate serum creatinine (sCr) increase and in the cut-off value applied, influences the prognostic value of Acute Kidney Injury (AKI).
Dhondt, Annemieke, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond, Vanmassenhove, Jill   +4 more
core   +2 more sources