Results 101 to 110 of about 2,251,236 (331)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Alterations of Renal Function Tests of Filling Station Workers with Respect of Genetic Polymorphisms of GSTM1 and GSTT1

پزشکی بالینی ابن سینا, 2004
The possible health effects of chronic exposure to petroleum products, in particular exposure to gasoline is an issue of public health concern. Filling station workers are at great risk of exposure to gasoline.
Maryam Ansari-Lari, Mostafa Saadat, Negin Hadi   +2 more
doaj  

Association of different glucose traits with kidney function decline risk in a Chinese community-based population without chronic kidney disease

, 2018
Xingang Wang,1 Fangfang Fan,1 Jia Jia,1 Xin Xu,2 Xianhui Qin,2 Bo Zheng,1 Haixia Li,3 Liguang Dong,4 Shuyu Wang,5 Jianping Li,1 Yong Huo,1 Jingtao Dou,6 Yan Zhang1 1Department of Cardiology, Peking University First Hospital, Beijing, China; 2National ...
Li H, Li J, Dou J, Qin X, Dong L, Jia J, Fan F, Wang S, Huo Y, Zhang Y, Zheng B, Wang X, Xu X   +12 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Evaluation of Serum Cystatin C levels in Type 2 Diabetes Mellitus Patients with and without Diabetic Nephropathy: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Diabetes Mellitus (DM) is a metabolic disorder characterised by insufficient insulin secretion or action that raises blood glucose levels.
Sangeeta Chongtham, Ngangom Arunkumar Singh, Takhellambam Brojen Singh, Niketa Ashem, Okram Reshmi, Moirangthem Sinorita Devi, Soibam Pritam Singh, RK Vallentina   +7 more
doaj   +1 more source

Assessment of a novel biomarker panel for the earlier prediction of acute kidney injury in patients with diabetes mellitus undergoing coronary angiography and intervention

, 2012
PhDDiabetes mellitus triples the risk of developing coronary heart disease (CHD). The manifestations of CHD are more severe in patients with diabetes with both more extensive and more diffuse disease.
Qureshi, Ayesha
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

KINETIC CHANGES OF KIDNEY FUNCTION TESTS AMONG PATIENTSWITH KIDNEY FAILURE IN ROYAL MEDICAL SERVICES

, 2015
Introduction: Kidney function tests are requested to monitor the general status of kidney health in general, and particularly to assess renal failure status.
Al Mawajdeh, Faten Thalji, Almahawish, Sheraf Said Mufleh, Alshakhanbeh, Esra Abed Ali, Alfalahat, Mai Mohammad, Hayajneh, Maisan Mahmoud, Al-Abdallat, Mais Elian, Abeele, Jaafar Abu   +6 more
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source