Results 81 to 90 of about 639,789 (302)

Cardiorespiratory fitness and sports activities in children and adolescents with solitary functioning kidney [PDF]

, 2016
Background: An increasing number of children with chronic disease require a complete medical examination to be able to practice physical activity. Particularly children with solitary functioning kidney (SFK) need an accurate functional evaluation to ...
DE CASTRO, Giovanna, DUSE, MARZIA, Falsaperla, R, FAVORITI, ALESSANDRA, LAMBIASE, CATERINA, LUBRANO, Riccardo, Paoli, S, Ricupito, F, TANCREDI, Giancarlo, Vitaliti, G, ZICARI, Anna Maria   +10 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Correlação entre a depuração plasmática de creatinina utilizando urina coletada durante 24 horas e 12 horas Correlation between the creatinine clearance in the urine collected during 24 hours and 12 hours

Brazilian Journal of Nephrology, 2010
INTRODUÇÃO: A concentração da creatinina no plasma é usada para avaliar a função renal, mas a depuração da creatinina plasmática (DCP) constitui método mais sensível para essa finalidade.
Amilcar Bernardo Tomé da Silva, Maria del Carmen Bisi Molina, Sérgio Lamêgo Rodrigues, Enildo Broetto Pimentel, Marcelo Perim Baldo, José Geraldo Mill   +5 more
doaj   +1 more source

Dental amalgam fillings: An under-investigated source of mercury exposure [PDF]

, 2019
Dental amalgam fillings, which contain about 50% mercury, have been used since the early 19th century. However, their use has been controversial, particularly because they continually release small amounts of mercury.
Ahlqwist, Ahlqwist, Ahlqwist, Bailer, Bangsi, Barregard, Barregard, Barregard, Bates, Bellinger, Bellinger, Bellinger, Bjorkman, Bjørklund, Boyd, Bratel, Bratel, Casetta, Clarkson, Clarkson, Counter, Daniels, de Burbure, DeRouen, Dye, Eti, Factor-Litvak, Ganss, Goldwater, Gun, Herrstrom, Herrstrom, Herrstrom, Herrstrom, Hsu, Hujoel, Hyson, Kingman, Lund, Malt, McGrother, Melchart, Nylander, Rothwell, Sandborgh-Englund, Saxe, Saxe, Schuurs, Seidler, Siblerud, Siblerud, Siblerud, Soler, Sun, Woods, World Health Organization   +55 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A study of pulmonary function in end-stage renal disease patients on hemodialysis: a cross-sectional study

São Paulo Medical Journal
BACKGROUND: The aim here was to study acute effects of hemodialysis among end-stage renal disease (ESRD) patients. DESIGN AND SETTING: Prospective study in tertiary-level care center. METHODS: Fifty ESRD patients undergoing hemodialysis were studied.
Ashima Sharma, Ashok Sharma, Sushila Gahlot, Pawan Kumar Prasher   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Narrative Review of Incremental Hemodialysis. [PDF]

, 2020
The prescription of hemodialysis (HD) in patients with incident end-stage kidney disease (ESKD) is fundamentally empirical. The abrupt transition from nondialysis chronic kidney disease (CKD) to thrice-weekly in-center HD of much the same dialysis ...
Garneata, Liliana, Kalantar-Zadeh, Kamyar, Moossavi, Shahriar, Murea, Mariana   +3 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Alterations of Renal Function Tests of Filling Station Workers with Respect of Genetic Polymorphisms of GSTM1 and GSTT1

پزشکی بالینی ابن سینا, 2004
The possible health effects of chronic exposure to petroleum products, in particular exposure to gasoline is an issue of public health concern. Filling station workers are at great risk of exposure to gasoline.
Maryam Ansari-Lari, Mostafa Saadat, Negin Hadi   +2 more
doaj