Results 81 to 90 of about 1,655,494 (303)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Kidney Stone Risk in Normocalcemic Hyperparathyroidism before and after Parathyroid Surgery

Case Reports in Endocrinology
The higher risk for kidney stone in patients with primary hyperparathyroidism is well-documented; stone risk in patients with normocalcemic primary hyperparathyroidism (NPHPT) remains unclear.
Jie Tang, Kamil Malshy, Gyan Pareek
doaj   +1 more source

Association of kidney stone disease with dietary factors: a review

Anthropological Review, 2020
Kidney stone disease is one of the most common urologic disorders worldwide. The incidence of kidney stones disease is increasing all over the world. It is a multifactorial disease accompanied by various factors.
Konjengbam Henry, Meitei Sanjenbam Yaiphaba   +1 more
doaj   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Factors Affecting Stone-freeness in the Initial Session of RIRS in Childhood Kidney Stones

Journal of Urological Surgery
Objective: To determine, the factors affecting stone-freeness in children after one session of retrograde intrarenal surgery (RIRS). Materials and Methods: The data of 102 children who applied RIRS in our clinic between February 2012-January 2022 were ...
Onur Kaygısız, Yavuz Mert Aydın, Levent Turan, Burhan Coşkun   +3 more
doaj   +1 more source

Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis [PDF]

International Brazilian Journal of Urology
Purpose: This prospective study aimed to identify risk factors associated with progression to stage 3 chronic kidney disease (CKD) and the occurrence of kidney stone formation or growth following nephrectomy for urolithiasis. Materials and methods: From
Thiago Augusto Cunha Ferreira, Alexandre Danilovic, Samirah Abreu Gomes, Fabio Carvalho Vicentini, Giovanni Scala Marchini, Fábio César Miranda Torricelli, Carlos Alfredo Batagello, William Carlos Nahas, Eduardo Mazzucchi   +8 more
doaj   +1 more source

An Energy Autonomous Microneedle Array‐Based Sensing System for Continuous Biomarker Monitoring

Advanced Science, EarlyView.
This work presents an innovative self‐powered wearable biosensor system for real‐time monitoring of multiple biomarkers in interstitial fluid. The device integrates stainless steel‐based minimally invasive microneedles with ion‐selective membranes, enabling simultaneous Na+, K+, Ca2+, pH, and glucose detection.
Arnab Pal, Kai‐Po Fan, Sheng‐Chun Hung, Jaba Roy Chowdhury, Jun‐Hsun Chung, Meenakshi Ray, Hsiang‐Yun Hsu, Fu‐Cheng Kao, Kuei‐Lin Liu, Zong‐Hong Lin   +9 more
wiley   +1 more source

Thiazide Diuretic Dose and Risk of Kidney Stones in Older Adults: A Retrospective Cohort Study

Canadian Journal of Kidney Health and Disease, 2018
Background: Thiazide diuretics are commonly prescribed to prevent kidney stones. However, it is unclear whether higher doses confer greater benefit. Objective: To determine whether lower doses of thiazide diuretics confer a similar protective effect ...
R. Todd Alexander, Eric McArthur, Racquel Jandoc, Blayne Welk, Daniel G. Fuster, Amit X. Garg, Robert R. Quinn   +6 more
doaj   +1 more source

Prevalence and Trends in Kidney Stone Among Adults in the USA: Analyses of National Health and Nutrition Examination Survey 2007-2018 Data.

European Urology Focus, 2020
BACKGROUND The contemporary prevalence and trends of kidney stones are not clear. OBJECTIVE To evaluate the gender-specific prevalence and trends in kidney stones among the US population.
M. Abufaraj, Tianlin Xu, C. Cao, T. Waldhoer, C. Seitz, D. D’andrea, Abdelmuez Siyam, Rand Tarawneh, H. Fajkovic, E. Schernhammer, Lin Yang, S. Shariat   +11 more
semanticscholar   +1 more source