Results 61 to 70 of about 116,592 (344)

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

open access: yesAdvanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun   +17 more
wiley   +1 more source

Photothermal nanoparticles for ablation of bacteria associated with kidney stones

open access: yesInternational Journal of Hyperthermia, 2021
Objective To determine whether photothermal polymer nanoparticles (NPs) can interface with bacteria associated with kidney stones, generate heat when stimulated with near infrared (NIR) light, and aid in reducing bacterial burden.
Ilan Klein   +3 more
doaj   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

open access: yesAdvanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang   +9 more
wiley   +1 more source

Treatment of kidney stones: standards and innovations

open access: yesВестник урологии, 2019
Urolithiasis remains one of the most common diseases in urology. At the same time, kidney stones are the most common and relevant part of this problem.
P. V. Trusov, A. A. Gusev
doaj   +1 more source

An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring

open access: yesAdvanced Science, EarlyView.
Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar   +6 more
wiley   +1 more source

Kidney stones? It's time to rethink those meds [PDF]

open access: yes, 2016
Kidney stones? It's time to rethink those meds. Despite being recommended for ureteral stone expulsion, tamsulosin or nifedipine are no more effective than placebo.
Jarrett, Jennie B.   +2 more
core  

Non-spherical collapse of an air bubble subjected to a lithotripter pulse [PDF]

open access: yes, 2008
In order to better understand the contribution of bubble collapse to stone comminution in shockwave lithotripsy, the shockinduced and Rayleigh collapse of a spherical air bubble is investigated using numerical simulations, and the free-field collapse ...
Bailey, Michael R.   +3 more
core   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

Efficiency of the contact antegrade electro-pulse lithotripsy in the kidney stones treatment

open access: yesВестник урологии, 2020
Introduction. There remains a need to introduce new methods of treating kidney stones, given the increasing incidence of urolithiasis. Considering the proven efficacy and safety of retrograde electro-pulse lithotripsy, its use in the treatment of stones ...
A. V. Gudkov   +3 more
doaj   +1 more source

Barnes Hospital Bulletin [PDF]

open access: yes, 1985
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1237/thumbnail ...

core   +1 more source

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