Results 71 to 80 of about 1,664,785 (304)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Treatment of kidney stones: standards and innovations

Вестник урологии, 2019
Urolithiasis remains one of the most common diseases in urology. At the same time, kidney stones are the most common and relevant part of this problem.
P. V. Trusov, A. A. Gusev
doaj   +1 more source

Short‐Term Outcomes and Cost Drivers of Emergency Surgery for Acute Abdominal Disease in Super‐Elderly Patients: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study analyzed patients aged ≥ 85 years undergoing emergency abdominal surgery, focusing on short‐term outcomes and inpatient cost structure under the Japanese DPC system. Although major complications occurred in 19.4% of patients, more than 70% were discharged home.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shojiro Hata, Hirokazu Yamaguchi   +8 more
wiley   +1 more source

Polyfluoroalkyl chemicals and the risk of kidney stones in US adults: A population-based study.

Ecotoxicology and Environmental Safety, 2020
The potential nephrotoxicity of polyfluoroalkyl chemicals (PFCs) have received extensive attention. However, the relationship between PFCs and the risk of kidney stones remain unclear.
W. Mao, Q. Hu, Saisai Chen, Yu Chen, M. Luo, Ziwei Zhang, J. Geng, Jianping Wu, Bin Xu, Ming Chen   +9 more
semanticscholar   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

An Unusual Type of Kidney Stone

Clinical Laboratory, 2016
A very rare case of acetylsulfapyridine nephrolithiasis is presented in a 54-year-old female patient who had been prescribed sulfasalazine (6 x 500 mg/day) because of psoriatic arthritis for the last 9 years. The patient's renal function was only slightly impaired.
DE KONINCK, ANNE-SOPHIE, GROEN, LUITZEN ALBERT, MAES, HELEEN, Verstraete, Alain, Stove, Veronique, Delanghe, Joris   +5 more
openaire   +5 more sources

Association between physical activity and kidney stones based on dose-response analyses using restricted cubic splines.

European Journal of Public Health, 2020
BACKGROUND This study aimed to determine whether there is a dose-response relationship between physical activity and the self-reported prevalence of kidney stone, based on a restricted cubic splines (RCS) method. METHODS This study analyzed 8931 adults
Xiaojie Feng, Wentao Wu, Fanfan Zhao, Fengshuo Xu, Didi Han, Xiaojuan Guo, Jun Lyu   +6 more
semanticscholar   +1 more source

Bioconvective Unsteady Casson Hybrid Nanofluid Flow on a Variable Darcy Regime Between Two Rotating Disks With Variable Heat Source

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This study carries significant consequences in various engineering applications, such as cooling rotating disk surfaces, improving chemical reactor performance, and designing filtration systems. Considering these main applications in view, the aim of this study is to investigate time‐dependent Casson hybrid nanofluid flow on a permeable ...
Ebrahem A. Algehyne, Abdul Bariq, Mounirah Areshi, Fahad Maqbul Alamrani, Zehba Raizah, Izharul Haq, Anwar Saeed   +6 more
wiley   +1 more source

Efficiency of the contact antegrade electro-pulse lithotripsy in the kidney stones treatment

Вестник урологии, 2020
Introduction. There remains a need to introduce new methods of treating kidney stones, given the increasing incidence of urolithiasis. Considering the proven efficacy and safety of retrograde electro-pulse lithotripsy, its use in the treatment of stones ...
A. V. Gudkov, V. S. Boshchenko, M. S. Lozovskiy, E. M. Tilashov   +3 more
doaj   +1 more source