Results 81 to 90 of about 116,592 (344)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Association between triglyceride-glucose index and nephrolithiasis among the elderly in Amirkola: A cross-sectional population-based study [PDF]

Caspian Journal of Internal Medicine
Background: Kidney stones are a condition that is prevalent in the geriatric group and significantly impairs their quality of life. The formation of stones may be associated with insulin resistance, which can be measured using the triglyceride-glucose ...
Parsa Aghajani, Seyed Reza Hosseini, Ali Bijani, Reza Ghadimi   +3 more
doaj  

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Cutting head for ultrasonic lithotripsy [PDF]

A cutting head for attachment to the end of the wire probe of an ultrasonic kidney stone disintegration instrument is described. The cutting head has a plurality of circumferentially arranged teeth formed at one end thereof to provide a cup shaped ...
Anguluo, E. D., Goodfriend, R.
core   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Catechol Derivative‐Based Bioadhesives: Molecular Design for Precision Medical Adhesion

Advanced Science, EarlyView.
This study utilizes tree‐inspired side‐chain engineering to graft five catechol derivatives onto PVA, systematically revealing how side‐chain length and substituents regulate adhesion and cohesion properties. Among them, the PVA‐CA patch demonstrates superior tissue adhesion, biocompatibility, and promotes regeneration, establishing a programmable ...
Xueyu Wang, Zixin Yang, Shan Wang, Weiwei Tan, Zhirui He, Qinyu Duan, Huanan Wang, Tao Chen, Shanshan Hu   +8 more
wiley   +1 more source

When is choice a good thing?: An experimental study of the impact of choice on patient outcomes [PDF]

, 2008
The official published version can be obtained from the link below - Copyright @ Taylor & FrancisAlthough policy emphasises the benefits of choice, an increasing body of work points to times when choice may not always have positive consequences.
Barnett, J, Daniells, E, Ogden, J
core   +2 more sources

Reply to Wei Wang and Guowei Shi’s Letter to the Editor re: Mathew D. Sorensen, Jonathan D. Harper, Michael S. Borofsky, et al. Removal of Small, Asymptomatic Kidney Stones and Incidence of Relapse. N Engl J Med 2022;387:506–13 [PDF]

, 2022
Mathew D. Sorensen, Michael R. Bailey, Jonathan D. Harper   +2 more
openalex   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, EarlyView.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Association between dietary niacin intake and kidney stones in American adults

Scientific Reports
The evidence regarding the relationship between dietary niacin intake and kidney stones is limited. This study aims to investigate the association of dietary niacin intake with the prevalence of kidney stones among adults in the United States.
Jian Wu
doaj   +1 more source