Results 101 to 110 of about 2,281,812 (411)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome [PDF]

, 2019
Donor-reactive immunity plays a major role in rejection after kidney transplantation, but analysis of donor-reactive T-cells is not applied routinely. However, it has been shown that this could help to identify patients at risk of acute rejection.
Babel, Nina, Choi, Mira, Kurtz, Andreas, Lachmann, Nils, Mueskes, Annemarie, Nickel, Peter, Reinke, Petra, Roch, Toralf, Rosiewicz, Kamil, Schmueck-Henneresse, Michael, Stein, Maik, Stervbo, Ulrik, Thieme, Constantin J., Wehler, Patrizia, Weist, Benjamin J. D., Westhoff, Timm H.   +15 more
core   +1 more source

Barriers to living donor kidney transplantation in the United Kingdom: a national observational study

Nephrology, Dialysis and Transplantation, 2017
Background. Living donor kidney transplantation (LDKT) provides more timely access to transplantation and better clinical outcomes than deceased donor kidney transplantation (DDKT). This study investigated disparities in the utilization of LDKT in the UK.
Diana A. Wu, M. Robb, C. Watson, J. Forsythe, C. Tomson, J. Cairns, P. Roderick, Rachel J. Johnson, R. Ravanan, D. Fogarty, C. Bradley, Andrea Gibbons, W. Metcalfe, H. Draper, A. Bradley, G. Oniscu   +15 more
semanticscholar   +1 more source

Laparoscopic Kidney Transplantation

European Urology, 2010
We present the details of the first laparoscopic transplantation of a kidney from a living, related donor, performed April 16, 2009. Surgical and functional results were acceptable. Surgical time was 240 min (53 min for vascular suture), with blood loss of 300 cm(3) and a hospital stay of 14 d. Serum creatinine at discharge was 73 mmol/l.
Luis Guirado, S. Esquena, Guillermo Urdaneta, M. Montlleó, José Salvador, Antonio Rosales, J. Caffaratti, Humberto Villavicencio, Javier Ponce de León, Dyler Patiño   +9 more
openaire   +4 more sources

Engineered MSC Aggregates with E/N‐Cadherin and IL‐6 Preconditioning for the Treatment of Systemic Sclerosis

Advanced Healthcare Materials, EarlyView.
Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang, Mengyuan Qian, Yirui Shi, Jiaxu Cao, Min Xu, Xin Wen, Yunxia Yan, Sha Liu, Hongwei Chen, Shanshan Liu, Jun Yang, Lingyun Sun   +11 more
wiley   +1 more source

A growing transplanted kidney [PDF]

Clinical Kidney Journal, 2010
Sir, Renal sinus lipomatosis (RSL) is a rare disease, described by replacement of parenchyma by sinus and/or perirenal fat. We report here an exceptional case of RSL on kidney graft after corticosteroid treatment was stopped, leading to functional graft transplantectomy. A 74-year-old man received a first renal allograft in 2004.
Bruno Turlin, Morgane Gosselin, Patrick Le Pogamp, Jerome Potier, Cécile Vigneau   +4 more
openaire   +3 more sources

Photocrosslinkable Kidney Decellularized Extracellular Matrix‐Based Bioink for 3D Bioprinting

Advanced Healthcare Materials, EarlyView.
A photocrosslinkable bioink is developed from methacrylated decellularized porcine kidney extracellular matrix to create kidney‐specific 3D constructs. This bioink supports high cell viability, promotes multicellular spheroid formation, and enables stable multilayer bioprinting with tunable mechanical properties, providing a versatile platform for ...
Jaemyung Shin, Nima Tabatabaei Rezaei, Subin Choi, Zhangkang Li, Deok‐Ho Kim, Keekyoung Kim   +5 more
wiley   +1 more source

Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation [PDF]

, 2006
Objective: Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid ...
Abhay N. Vats, Adrianna Zeevi, Akhtar S. Khan, Amadeo Marcos, Amit Basu, Bartosh, Calne, Calne, Chakrabarti, Corde McFeaters, Demetrius Ellis, Edward A. Gray, Fine, Gerri James, Halloran, Henkie P. Tan, Jensen, Kirk, Knechtle, Lilly, Mary Jo Grosso, McCurry, Michael L. Moritz, Mueller, Najarian, Nankivell, Purighalla, Randhawa, Reyes, Riley, Ron Shapiro, Sarwal, Shapiro, Shapiro, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Stuart, Thomas E. Starzl, Todo, Waldmann, Williams   +52 more
core   +1 more source

COVID-19 and kidney transplantation

La Presse medicale, 2022
Sophie Caillard
semanticscholar   +1 more source

Kidney Exchange to Overcome Financial Barriers to Kidney Transplantation

American Journal of Transplantation, 2017
Organ shortage is the major limitation to kidney transplantation in the developed world. Conversely, millions of patients in the developing world with end‐stage renal disease die because they cannot afford renal replacement therapy—even when willing ...
Michael A. Rees, Ty B. Dunn, Christian S. Kuhr, Christopher L. Marsh, Jeffrey Rogers, Susan E Rees, Alejandra Cicero, Laurie Reece, Alvin E Roth, O. Ekwenna, D. Fumo, K. Krawiec, J. Kopke, Samay Jain, Miguel Tan, S. Paloyo   +15 more
semanticscholar   +1 more source