Results 61 to 70 of about 2,170,450 (367)

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

Nature Communications, 2019
Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but assessing their consistency and reproducibility across iPSC lines, and reducing the generation of off-target cells remain an open challenge.
Ayshwarya Subramanian, Eriene-Heidi Sidhom, M. Emani, K. Vernon, N. Sahakian, Yiming Zhou, M. Kost-Alimova, M. Slyper, Julia Waldman, Danielle Dionne, Lan Nguyen, Astrid Weins, Jamie L. Marshall, Orit Rosenblatt-Rosen, A. Regev, A. Greka   +15 more
semanticscholar   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

RECONSTRUCTIVE OPERATIONS ON THE PERMANENT VASCULAR ACCESS FOR HEMODIALYSIS

Вестник трансплантологии и искусственных органов, 2010
In patients with end stage renal failure it is vitally necessary to have permanent long functioning vascular access, providing all requirements of modern hemodialysis.
V. I. Lotts, L. E. Osipov, V. N. Sergeev
doaj   +1 more source

Efficacy and Safety of Sofosbuvir‐Based Antiviral Therapy to Treat Hepatitis C Virus Infection After Kidney Transplantation

American Journal of Transplantation, 2016
There is no approved therapy for hepatitis C virus (HCV) infection after kidney transplantation, and no data regarding the use of new‐generation direct antiviral agents (DAAs) have been published so far.
N. Kamar, O. Marion, L. Rostaing, O. Cointault, D. Ribes, L. Lavayssière, L. Esposito, A. D. Bello, S. Metivier, K. Barange, J. Izopet, L. Alric   +11 more
semanticscholar   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Clinical outcomes of kidney transplantation from expanded-criteria donors and KDPI>85% kidneys in deceased Chinese donors

BMC Nephrology
Background Kidney transplantation is the optimal treatment for end-stage renal disease; however, the limited availability of donor kidneys hinders the advancement of this procedure.
Kankan Shui, Hedong Zhang, Tengfang Li, Jianfei Hou, Gongbin Lan, Fenghua Peng, Shaojie Yu, Xubiao Xie, Helong Dai, Longkai Peng   +9 more
doaj   +1 more source

Trends of kidney transplantation in Japan in 2018: data from the kidney transplant registry

Renal Replacement Therapy, 2019
The number of kidney transplants has gradually increased in the last decade; it was 1742 in Japan in 2017. The outcomes have improved year by year, with the indications for transplantation expanding accordingly.
Takashi Yagisawa, Makiko Mieno, Naotsugu Ichimaru, Ken Morita, Michio Nakamura, Kiyohiko Hotta, Takashi Kenmochi, Kenji Yuzawa   +7 more
doaj   +1 more source

Hemophagocytic lymphohistiocytosis secondary to virus infection and followed by lupus nephritis recurrence in a renal transplantation pediatric recipient: a case report

BMC Nephrology, 2023
Background Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disorder characterized by systemic inflammation and organ failure as a result of dysregulated immune cell activation.
Jiyuan Li, Chen Gao, Xuejing Zhu, Danyi Yang, Wendan Mao, Hengchang Yao, Mingyang Deng, Liang Tan, Helong Dai, Xubiao Xie, Longkai Peng, Fenghua Peng   +11 more
doaj   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source