Results 61 to 70 of about 268,886 (314)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Life on the list: an exploratory study of the life world of individuals waiting for a kidney transplant [PDF]

, 2010
Kidney transplantation is the treatment of choice for many individuals with end stage renal disease (ESRD), as transplantation is reported to offer a greater quality of life than renal dialysis.
Long-Sutehall, Tracy, Frankland, Jane, Addington-Hall, Julia, Sque, Magi, Mason, Juan   +4 more
core  

Simultaneous Pancreas and Kidney Composite Graft Transplantation with Retroperitoneal Systemic-Enteric Drainage [PDF]

, 2014
Background: Simultaneous pancreas and kidney transplantation is the treatment of choice for diabetes mellitus patients with associated end-stage renal disease.
Ono, Shinichiro, Adachi, Tomohiko, Shyr, Yi-Ming, Kitazato, Amane, Kuroki, Tamotsu, Chen, Shin-Chin, Eguchi, Susumu, Chen, Yin-Yin, Wang, Shin-E   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bortezomib in Kidney Transplantation [PDF]

Journal of Transplantation, 2010
Although current therapies for pretransplant desensitization and treatment of antibody-mediated rejection (AMR) have had some success, they do not specifically deplete plasma cells that produce antihuman leukocyte antigen (HLA) antibodies. Bortezomib, a proteasome inhibitor approved for the treatment of multiple myeloma (a plasma cell neoplasm ...
Rajeev Raghavan, Abdallah Jeroudi, Katafan Achkar, A. Osama Gaber, Samir J. Patel, Abdul Abdellatif   +5 more
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts. [PDF]

, 1996
Mycophenolate mofetil (MMF) interacts with purine metabolism and possibly with the expression of adhesion molecules. In the present study, we analysed the expression of these molecules in transplanted kidney allografts treated with RS LBNF1 kidneys were ...
Nicholas Tilney, Tilney, N., Peter Hamar, Thomas Philipp, Schmid, C., Philipp, T., Christoph Schmid, Hamar, Péter, Uwe Heemann, Haruhito Azuma, Heemann, Uwe, Azuma, H.   +11 more
core   +1 more source

Recurrence of FSGS after Kidney Transplantation in Adults [PDF]

, 2020
Background and objectivesFSGS recurrence after kidney transplantation is a major risk factor for graft loss. However, the natural history, clinical predictors, and response to treatment remain unclear because of small sample sizes and poor ...
Riella, Leonardo, Nikhil Agrawal, Carlos Arias-Cabrales, Agena, Fabiana, Akalin, Enver, Stefan P. Berger, Omar Alani, Enver Akalin, Saif A. Muhsin, Miguel Carlos Riella, Anna Buxeda, David-Neto, Elias, Paolo Cravedi, Maria José Pérez-Sáez, Elias David-Neto, Comai, Giorgia, Marilda Mazzali, Gilberto M.V. Neto, Jose Perez-Saez, Maria, Andrea Carla Bauer, Hokazono, Silvia R., Roberto C. Manfro, Silvia R. Hokazono, Bugnazet, Mathilde, Thomas Jouve, Arias-Cabrales, Carlos, Michelle M. O’Shaughnessy, La Manna, Gaetano, Samira S. Farouk, Frederico de Sottomaior Drumond, Manfro, Roberto C., Audrey Uffing, Juliana B. Mansur, Bauer, Andrea Carla, Meredith Haverly, Alani, Omar, Farouk, Samira S., Bini, Claudia, Gaetano La Manna, Riella, Miguel Carlos, Neto, Gilberto M., Malvezzi, Paolo, Berger, Stefan P., Giorgia Comai, Cheng, Xingxing S., Cravedi, Paolo, Leonardo V. Riella, Haverly, Meredith, Mothi, Suraj Sarvode, Muhsin, Saif A., Mathilde Bugnazet, Claudia Bini, Tedesco-Silva Jr, Helio, Kuo-Kai Chin, Mansur, Juliana B., Chin, Kuo-Kai, Paolo Malvezzi, Ventura, Carlucci G., Suraj Sarvode Mothi, Jouve, Thomas, Drumond, Frederico de Sottomaior, Gianna Mastroianni Kirsztajn, Carlucci G. Ventura, Mazzali, Marilda, Kirsztajn, Gianna Mastroianni, Agrawal, Nikhil, Buxeda, Anna, Helio Tedesco-Silva, Uffing, Audrey, O'Shaughnessy, Michelle M., Fabiana Agena, Xingxing S. Cheng   +71 more
core   +1 more source

MCT1 inhibition reprograms Treg metabolism via ABC transporters: implications for tumor immunity and the prognosis of acute myeloid leukemia patients

European Journal of Medical Research
Glycolysis plays a critical role in regulatory T cells (Tregs), which are frequently exploited by tumor cells, as Treg survival depends on glycolytic activity to suppress antitumor immunity.
Ziyu Wang, Hongyang Wang, Qinghai Wang, Tao Huang, Chen Guo, Jianlei Ji, Zhen Dong, Yanwei Cao   +7 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source