PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubulesResearch in context
EBioMedicine, 2018 Background: The renal tubules, which have distant metabolic features and functions in different segments, reabsorb >99% of approximately 180 l of water and 25,000 mmol of Na + daily.
Zhongshi Lyu +9 more
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Expression of the plasma prekallikrein gene: utilization of multiple transcription start sites and alternative promoter regions [PDF]
, 2005 The plasma prekallikrein gene is expressed in many different human tissues at distinctly different levels and therefore tissue-specific control of the gene transcription is likely.
Akita +12 more
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Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane [PDF]
, 2012 Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation.
Andrews +26 more
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Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
Expression of metallothionein in renal tubules of rats exposed to acute and endurance exercise.
Folia Histochemica et Cytobiologica, 2006 The induction of exercise-induced apoptosis in not actively involved in exercise organs, such as kidney could be a result of oxidative stress. Metallothionein (MT) exerts a protective effect in the cell against oxidative stress and apoptosis.
Katia Rossini +8 more
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Streptozotocin induced hyperglycemia in the axolotl
Developmental Dynamics, EarlyView.Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen +2 more
wiley +1 more source
BMP-7 Protein Expression Is Downregulated in Human Diabetic Nephropathy
Acta Clinica Croatica, 2015 Bone morphogenetic protein-7 (BMP-7) is expressed in all parts of the normal kidney parenchyma, being highest in the epithelium of proximal tubules. It protects kidney against acute and chronic injury, inflammation and fibrosis.
Renata Ivanac-Janković +5 more
doaj
Biionic potentials in the proximal tubule of Necturus kidney [PDF]
The Journal of Physiology, 1973 1. Biionic potentials were studied in the proximal tubule of the doubly perfused Necturus kidney and subsequently analysed by means of an equivalent electrical circuit.2. Luminal membrane resistance was found to be at least 3 times greater than peritubular membrane resistance.3.
openaire +2 more sources
The role of aquaporins in the kidney of euryhaline teleosts [PDF]
, 2011 Water balance in teleost fish is maintained with contributions from the major osmoregulatory organs: intestine, gills and kidney. Overall water fluxes have been studied in all of these organs but not until recently has it become possible to approach the ...
Engelund, Morten Buch, Madsen, Steffen S
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