Results 261 to 270 of about 1,118,511 (368)

Silver Nanoparticle-Induced Nephrotoxicity in Zebrafish (<i>Danio rerio</i>). [PDF]

Int J Mol Sci
Okuthe GE, Siguba B.
europepmc   +1 more source

Tracing the molecular landscape of diabetic nephropathy: Insights from machine learning and experiment verification

Journal of Diabetes Investigation, EarlyView.
Diabetic nephropathy (DN) is a major complication of diabetes, leading to end‐stage renal disease. This study identified 109 differentially expressed genes (DEGs) and validated LOX as a novel diagnostic biomarker through integrated bioinformatics and experimental analysis.
Shahad W. Kattan, Ahmed M. Basri, Mohammad H. Alhashmi, Amany I. Almars, Reem Hasaballah Alhasani, Ifat Alsharif, Ikhlas A. Sindi, Ahmad H. Mufti, Iman S. Abumansour, Nasser A. Elhawary, Aishah Abdullah Qahtani, Hailah M. Almohaimeed   +11 more
wiley   +1 more source

Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats

Journal of Diabetes Investigation, EarlyView.
While SGLT2 accounts for >90% of kidney glucose reabsorption, its pharmacological inhibition or genetic knockdown reduces glucose reabsorption by only 50%. We found that the SGLT2 inhibitor, dapagliflozin, induced an early, transient hyperplastic response in the SGLT1‐expressing S3 segment of the proximal tubule followed by an increase in its length ...
Ellen Wu, Sarah Macklin, Yanling Zhang, Kerri Thai, Linda Nghiem, Caterina Di Ciano‐Oliveira, Nuno Coelho, Hai Wang, Suzanne L. Advani, Jean‐François Desjardins, Darren A Yuen, Paraish Misra, Kim A. Connelly, Jens R. Nyengaard, Richard E. Gilbert   +14 more
wiley   +1 more source

Assessment of untreated and vermifiltration treated pharmaceutical industrial effluent in fish Channa punctata using biochemical, histopathological, ultrastructural and ATR-FTIR analysis. [PDF]

Sci Rep
Kaur H, Chadha P.
europepmc   +1 more source

Clinical use and monitoring of adverse effects of sodium‐glucose cotransporter‐2 inhibitors in persons with type 1 diabetes mellitus

Journal of Diabetes Investigation, EarlyView.
Multiple regression analysis revealed that diuretic use was an independent risk factor for discontinuation of SGLT2i. ABSTRACT Aims This study aimed to evaluate the factors contributing to insulin dosage adjustment and the risk of sodium‐glucose cotransporter‐2 inhibitor (SGLT2i) discontinuation in persons with type 1 diabetes mellitus (T1DM) starting ...
Chinatsu Sakai, Shinichi Tamaru, Keiji Sugai, Hironori Takeuchi, Ryo Suzuki   +4 more
wiley   +1 more source

METTL3/YTHDF3 m6A axis promotes ferroptosis in diabetic kidney disease by stabilizing TfR1

Journal of Diabetes Investigation, EarlyView.
METTL3/YTHDF3 m6A axis promoted ferroptosis in DKD by stabilizing TfR1, which could provide a reference for DKD treatment. ABSTRACT Objective Diabetic kidney disease (DKD) is a common complication of diabetes. N6‐Methyladenosine (m6A) modification is a widely studied epigenetic mechanism.
Jinmei Zhang, Xiaoping Zhou, Bin Wang, Yan Yin, Daihao Wei, Kun Li   +5 more
wiley   +1 more source

Autophagic stagnation: a key mechanism in kidney disease progression linked to aging and obesity. [PDF]

Clin Exp Nephrol
Yamamoto T.
europepmc   +1 more source

The Pathology and Blood Biochemistry of Juvenile Lates calcarifer on Diets Contaminated With Mycotoxins, Histamines and Rancid Fats—A Case Study

Journal of Fish Diseases, EarlyView.
ABSTRACT Mycotoxins, originating from contaminated raw materials or suboptimal feed storage, are a growing concern in tropical aquaculture. Common fungi such as Aspergillus spp. and Fusarium spp. produce mycotoxins including aflatoxin, fumonisin, deoxynivalenol and zearalenone. High doses or prolonged exposure (weeks) to low doses of these mycotoxins (<
Aidan Kwok, Jose A. Domingos, Joseph Oh, Piero Chan, Joyce J. L. Ong, Leo Nankervis, Jeffrey Ling, Robert Nichol, Susan Gibson‐Kueh   +8 more
wiley   +1 more source

Tubular damage and SGLT2 expression in a patient with Beni-koji tablet-associated acute kidney injury and Fanconi syndrome. [PDF]

CEN Case Rep
Kamada A, Hirose T, Hashimoto H, Konya Y, Sato F, Ishiyama K, Joh K, Yumura W, Mori T.   +8 more
europepmc   +1 more source

Effects of sex hormones on the development of giant lysosomes in the proximal tubules of DBA/2Cr mouse kidney

, 2003
Akira Yabuki, Syusaku SUZUKI, Mitsuharu Matsumoto, Hayao NISHINAKAGAWA   +3 more
openalex   +2 more sources