Results 191 to 200 of about 85,466 (268)

Stakeholder perspectives of barriers and facilitators to enhancing hydration in elementary schools within a socio-ecological framework. [PDF]

Front Public Health
Tatum KL, Smith DI, Hung HS, Weinstock M, Rhodenhiser S, Blincoe J, Brewer AE, LaRose JG, Erby T, Haskins L, Starlings K, Garr K, Brickhouse TH, Bean MK, Hydration Community Advisory Board.   +14 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Mechanisms of impaired glucose transport in cryptosporidiosis in goat kids. [PDF]

BMC Vet Res
Krasilnikova V, Kuzmina E, Philippova A.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Yomix: an interactive tool for the exploration of low-dimensional embeddings in omics data. [PDF]

Bioinformatics
Perrin-Gilbert N, Amjad N, Fumeron P, Tulli S, Waterfall JJ.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Evaluation of Oral Supplementation of Black Cumin (Nigella sativa) on Growth Performance, Immune Response, Disease Incidence and Mortality Rate of Suckling Zaraibi Goat Kids. [PDF]

Vet Med Sci
Gaafar HM, Dell'Anno M, El-Nahrawy MM, Abdou AA, Elkersh MF, Mesbah RA, Rossi L, El-Esawy GS.   +7 more
europepmc   +1 more source

Balance and physical activity in teenagers and young adults with cochlear implants: a Swedish cohort study. [PDF]

BMC Pediatr
Gripenberg S, Verrecchia L, Lidbeck C.
europepmc   +1 more source

Improved Growth and Reproductive Performance and Reshaped Gut Microbiota in Jining Grey Goats Through Nubian Crossbreeding. [PDF]

Animals (Basel)
Cao J, Li H, Lu Y, Wu A, Wang L, Liu T, Lian Z.   +6 more
europepmc   +1 more source