Results 61 to 70 of about 846,182 (334)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Some New Results on Trans-Sasakian Manifolds

Journal of Mathematics, 2022
In this paper, we classify trans-Sasakian manifolds which are realized as real hypersurfaces in a complex space form. We also investigate trans-Sasakian manifolds whose Reeb vector fields are harmonic-Killing.
Lei Wang, Yan Zhao
doaj   +1 more source

To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins [PDF]

Frontiers in Immunology, 2020
Pore-forming proteins (PFPs) are present in all domains of life, and play an important role in host-pathogen warfare and in the elimination of cancers. They can be employed to deliver specific effectors across membranes, to disrupt membrane integrity interfering with cell homeostasis, and to lyse membranes either destroying intracellular organelles or ...
Patrycja A. Krawczyk, Marco Laub, Patrycja Kozik   +2 more
openaire   +3 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Black hole and naked singularity geometries supported by three-form fields

European Physical Journal C: Particles and Fields, 2020
We investigate static and spherically symmetric solutions in a gravity theory that extends the standard Hilbert–Einstein action with a Lagrangian constructed from a three-form field $$A_{\alpha \beta \gamma }$$ Aαβγ , which is related to the field ...
Bruno J. Barros, Bogdan Dǎnilǎ, Tiberiu Harko, Francisco S. N. Lobo   +3 more
doaj   +1 more source

Hidden symmetry in the presence of fluxes

, 2010
We derive the most general first order symmetry operator for the Dirac equation coupled to arbitrary fluxes. Such an operator is given in terms of an inhomogenous form omega which is a solution to a coupled system of first order partial differential ...
Açik, Benn, Benn, Benn, Chong, Chow, Claude M. Warnick, Connes, Cvetic, David Kubizňák, De Jonghe, Gibbons, Houri, Houri, Kamran, Kubiznak, McLenaghan, Pavel Krtouš, Rietdijk, Semmelmann, Sen, Wu, Yano   +22 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Asymptotic symmetries on Kerr--Newman horizon without anomaly of diffeomorphism invariance [PDF]

, 2006
We analyze asymptotic symmetries on the Killing horizon of the four-dimensional Kerr--Newman black hole. We first derive the asymptotic Killing vectors on the Killing horizon, which describe the asymptotic symmetries, and find that the general form of ...
Carlip S, Carlip S, Carlip S, Frolov V, Frolov V P, Fursaev D V, Horowitz G T, Jun-ichirou Koga, Koga J, Ratz I, Ratz I, Sen A, Silva S, Strominger A, Wald R M   +14 more
core   +4 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Carbon Dots for Sensing and Killing Microorganisms

C, 2019
Carbon dots (or carbon quantum dots) are small (less than 10 nm) and luminescent carbon nanoparticles with some form of surface passivation. As an emerging class of nanomaterials, carbon dots have found wide applications in medicine, bioimaging, sensing,
Fengming Lin, Yan-Wen Bao, Fu-Gen Wu
doaj   +1 more source