Results 51 to 60 of about 30,853 (255)

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

open access: yesAdvanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu   +7 more
wiley   +1 more source

Ricci Solitons and Generalized Ricci Solitons Whose Potential Vector Fields Are Jacobi-Type

open access: yesJournal of Mathematics
This paper is devoted to Ricci solitons admitting a Jacobi-type vector field. First, we present some rigidity results for Ricci solitons Mn,g,V,λ admitting a Jacobi-type vector field ξ and provide conditions under which ξ is Killing.
Vahid Pirhadi   +2 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Killing vector fields with twistor derivative [PDF]

open access: yes, 2007
18 pagesInternational audienceMotivated by the possible characterization of Sasakian manifolds in terms of twistor forms, we give the complete classification of compact Riemannian manifolds carrying a Killing vector field whose covariant derivative ...
Moroianu, Andrei, Andrei Moroianu
core   +1 more source

Quadratic Killing tensors on symmetric spaces which are not generated by Killing vector fields

open access: yesComptes Rendus. Mathématique
Every Killing tensor field on the space of constant curvature and on the complex projective space can be decomposed into the sum of symmetric tensor products of Killing vector fields (equivalently, every polynomial in velocities integral of the geodesic ...
Matveev, Vladimir S., Nikolayevsky, Yuri
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Killing vector fields and holonomy algebras [PDF]

open access: yes, 1984
We prove that for each Killing vector field $ X$ on a complete Riemannian manifold, whose orthogonal distribution is involutive, the $ (1,1)$ skew-symmetric operator $ {A_X}$ associated to $ X$ by $ {A_X} = {L_X} - {\nabla _X}$ lies in the holonomy ...
Currás Bosch, Carlos   +1 more
core   +1 more source

Symmetries of supergravity backgrounds and supersymmetric field theory

open access: yesJournal of High Energy Physics, 2020
In four spacetime dimensions, all N $$ \mathcal{N} $$ = 1 supergravity-matter systems can be formulated in the so-called U(1) superspace proposed by Howe in 1981.
Sergei M. Kuzenko   +1 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

Harmonic-Killing vector fields on Kähler manifolds [PDF]

open access: yes, 2000
In a previous paper we have considered the harmonicity of local infinitesimal transformations associated to a vector field on a (pseudo)-Riemannian manifold to characterise intrinsically a class of vector fields that we have called harmonic-Killing ...
Dodson, Christopher   +2 more
core   +2 more sources

Home - About - Disclaimer - Privacy