Results 71 to 80 of about 8,017,385 (274)

Symmetries of supergravity backgrounds and supersymmetric field theory

Journal of High Energy Physics, 2020
In four spacetime dimensions, all N $$ \mathcal{N} $$ = 1 supergravity-matter systems can be formulated in the so-called U(1) superspace proposed by Howe in 1981.
Sergei M. Kuzenko, Emmanouil S.N. Raptakis   +1 more
doaj   +1 more source

CARTAN GEOMETRIES ON COMPLEX MANIFOLDS OF ALGEBRAIC DIMENSION ZERO [PDF]

Épijournal de Géométrie Algébrique, 2019
We show that compact complex manifolds of algebraic dimension zero bearing a holomorphic Cartan geometry of algebraic type have infinite fundamental group.
Indranil Biswas, Sorin Dumitrescu, Benjamin McKay   +2 more
doaj   +1 more source

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Geodesic connectedness of a spacetime with a causal Killing vector field. [PDF]

We study the geodesic connectedness of a globally hyperbolic spacetime (M, g) admitting a complete smooth Cauchy hypersurface S and endowed with a complete causal Killing vector field K.
Bartolo, Rossella
core  

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Effective field theory for non-relativistic hydrodynamics

Journal of High Energy Physics, 2020
We write down a Schwinger-Keldysh effective field theory for non-relativistic (Galilean) hydrodynamics. We use the null background construction to covariantly couple Galilean field theories to a set of background sources.
Akash Jain
doaj   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Generalized supergravity equations for the WZW model

Physics Letters B
Generalized supergravity equations (GSEs) were originally proposed as a modification of the standard IIB supergravity equations to satisfy the background of η-deformed AdS5×S5 introduced by Arutyunov et al.
Ali Eghbali, Simin Ghasemi-Sorkhabi, Adel Rezaei-Aghdam   +2 more
doaj   +1 more source