Results 111 to 120 of about 2,965,710 (272)

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

New Interpretations for the Riemann Curvature and the Landsberg Property in Homogeneous Finsler Geometry

Mathematics
In this paper, we provide a new Riemann curvature formula in homogeneous Finsler geometry. Meanwhile, we prove that a homogeneous Finsler metric is Landsberg if and only if its connection operator induces Killing vector fields for a Hessian metric. As an
Ming Xu, Xiaoyang Wang
doaj   +1 more source

The Interplay Between Molybdopterin Synthase and Metal Metabolism Contributes to Pathogenicity in Acinetobacter baumannii

Advanced Science, EarlyView.
Pathogenic Acinetobacter baumannii scavenges metal ions as nutritional elements to survive within the host. This study demonstrates that molybdopterin synthase is essential for pathogenesis and full virulence during infection. Molybdopterin synthase subunit MoaE constitutes an intrinsically disordered C‐terminal histidine rich tail, which mediates ...
Min Jiao, Wenbo He, Zhenlin Ouyang, Ruochen Wang, Jiaxin Zhang, Xin Liu, Yiting Jing, Qinyue Yu, Xiaoyu He, Qian Qin, Litao Guo, Peter M. Hwang, Fang Zheng, Yurong Wen   +13 more
wiley   +1 more source

18F‐FGln PET/CT Imaging of Glutamine Uptake Has Potential for Predicting Immunotherapy Response in Hepatocellular Carcinoma

Advanced Science, EarlyView.
18F‐FGln PET/CT imaging serves as a marker of Gln uptake in hepatocellular carcinoma. Tumors with high Gln uptake drive Treg‐mediated immunosuppression and immune evasion during antitumor immunotherapy. Conversely, tumors with low Gln uptake maintain sufficient Gln in the TME, suppressing Tregs and enabling cytotoxic T cells to inhibit tumor growth ...
Yi Liu, Jindian Li, Xiaoyu Pan, Xiaoping Xu, Xuan Huang, Simin He, Jianping Zhang, Fei Liu, Shaoli Song   +8 more
wiley   +1 more source

Reconstruction of Noether Symmetries and Their Application to the Derivation of Killing Vector Fields

Journal of Applied Mathematics
This work introduces a novel variational framework for the reconstruction of Noether symmetries for N-parameter point transformations. We demonstrate that the problem of finding symmetries can be reduced to the analysis of a single parameter via a linear
Emiliano Aguilar-Rivas, Ricardo Águila-Gómez, Ernesto Urenda-Cázares, Armando Gallegos, Miriam Bocardo-Gaspar   +4 more
doaj   +1 more source

Celestial sector in CFT: Conformally soft symmetries

SciPost Physics
We show that time intervals of width $\Delta \tau$ in 3-dimensional conformal field theories (CFT$_3$) on the Lorentzian cylinder admit an infinite dimensional symmetry enhancement in the limit $\Delta \tau → 0$.
Leonardo Pipolo de Gioia, Ana-Maria Raclariu
doaj   +1 more source

Behaviorally Adaptive and Inclusive Advanced Driver‐Assistance Systems

Advanced Intelligent Systems, EarlyView.
Advanced driver‐assistance systems (ADASs) are mapped as evolving human‐centered, adaptive technologies linking sensing, driver monitoring, AR/HUD interfaces, patents, regulation, and inclusive design. The review identifies gaps in real‐world evidence, diverse‐driver validation, gaze metrics, and governance, outlining a roadmap for safer, behaviorally ...
Jana Skirnewskaja, Mardavij Roozbehani, Munther A. Dahleh   +2 more
wiley   +1 more source

Orthonormal Right-Handed Frames on the Two-Sphere and Solutions to Maxwell’s Equations via de Broglie Waves

Mathematics
This paper explores some frame bundles and physical implications of Killing vector fields on the two-sphere S2, culminating in a novel application to Maxwell’s equations in free space.
David Carfì
doaj   +1 more source

Multi‐method analysis for the three‐dimensional reconstruction of muscle fascicles from DiceCT datasets

The Anatomical Record, EarlyView.
Abstract Muscle architecture is a major determinant of muscle performance and, in mammalian lineages, has been correlated with both feeding ecology and locomotor behaviors. Over the past decade, contrast‐enhanced micro‐CT (DiceCT) has emerged as an alternative to traditional dissection‐based measurement.
Aleksandra Ratkiewicz, Michael C. Granatosky, Cassidy E. Davis, Julia Molnar, Adam Hartstone‐Rose, Edwin Dickinson   +5 more
wiley   +1 more source

Chiral interactions of fermions and massive gauge fields in Kaluza-Klein models

Journal of High Energy Physics
In Kaluza-Klein theory, gauge fields on M 4 arise as components of a higher-dimensional metric defined on M 4 × K. The traditional expectation is that all the gauge fields of the Standard Model are linked to exact Killing vector fields on the internal ...
João Baptista
doaj   +1 more source