Results 101 to 110 of about 2,793,586 (269)
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Complex surfaces and null conformal Killing vector fields
, 2022 We study the relation between the existence of null conformal Killing vector fields and existence of compatible complex and para-hypercomplex structures on a pseudo-Riemannian manifold with metric of signature (2,2).
Grantcharov, Gueo +2 more
core
Advanced Science, EarlyView.Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng +12 more
wiley +1 more source
Killing vector fields with twistor derivative
Journal of Differential Geometry, 2007 Motivated by the possible characterization of Sasakian manifolds in terms of twistor forms, we give the complete classification of compact Riemannian manifolds carrying a Killing vector field whose covariant derivative (viewed as a 2-form) is a twistor form.
openaire +3 more sources
On the Lie subalgebra of Killing-Milne and Killing-Cartan vector fields in Newtonian space-time
, 2014 The Galilean (and more generally Milne) invariance of Newtonian theory allows for Killing vector fields of a general kind, whereby the Lie derivative of a field is not required to vanish but only to be cancellable by some infinitesimal Galilean ...
Chamel, Nicolas
core +1 more source
Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
Advanced Science, EarlyView.Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song +7 more
wiley +1 more source
Advanced Science, EarlyView.In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang +8 more
wiley +1 more source
MathematicsIn this paper, we provide a new Riemann curvature formula in homogeneous Finsler geometry. Meanwhile, we prove that a homogeneous Finsler metric is Landsberg if and only if its connection operator induces Killing vector fields for a Hessian metric. As an
Ming Xu, Xiaoyang Wang
doaj +1 more source
Spectral Processing of Tangential Vector Fields
, 2017 We propose a framework for the spectral processing of tangential vector fields on surfaces. The basis is a Fourier‐type representation of tangential vector fields that associates frequencies with tangential vector fields.
Hildebrandt, Klaus +3 more
core +1 more source
CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation
Advanced Science, EarlyView.CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu +6 more
wiley +1 more source