Results 81 to 90 of about 2,965,710 (272)

Spinorial geometry, off-shell Killing spinor identities and higher derivative 5D supergravities

open access: yesJournal of High Energy Physics, 2018
Killing spinor identities relate components of equations of motion to each other for supersymmetric backgrounds. The only input required is the field content and the supersymmetry transformations of the fields, as long as an on-shell supersymmetrization ...
Federico Bonetti   +3 more
doaj   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song   +6 more
wiley   +1 more source

On the Potential Vector Fields of Soliton-Type Equations

open access: yesAxioms
We highlight some properties of a class of distinguished vector fields associated to a (1,1)-tensor field and to an affine connection on a Riemannian manifold, with a special view towards the Ricci vector fields, and we characterize them with respect to ...
Adara M. Blaga
doaj   +1 more source

Quadratic Killing tensors on symmetric spaces which are not generated by Killing vector fields [PDF]

open access: yes, 2023
Every Killing tensor field on the space of constant curvature and on the complex projective space can be decomposed into the sum of symmetric tensor products of Killing vector fields (equivalently, every polynomial in the velocities integral of the ...
Matveev, Vladimir S., Nikolayevsky, Yuri
core  

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

open access: yesAdvanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen   +10 more
wiley   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

open access: yesAdvanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He   +6 more
wiley   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

open access: yesAdvanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang   +4 more
wiley   +1 more source

Projective Vector Fields on Semi-Riemannian Manifolds

open access: yesMathematics
This paper explores the properties of projective vector fields on semi-Riemannian manifolds. The main result establishes that if a projective vector field P on such a manifold is also a conformal vector field with potential function ψ and the vector ...
Norah Alshehri, Mohammed Guediri
doaj   +1 more source

On completeness of orbits of Killing vector fields [PDF]

open access: yesClassical and Quantum Gravity, 1993
16 pages, Latex, preprint NSF-ITP-93 ...
openaire   +2 more sources

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

open access: yesAdvanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji   +11 more
wiley   +1 more source

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