Results 41 to 50 of about 6,955,734 (292)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
國際通商秩序上 多國籍企業의 人權保障에 관한 所論 [PDF]
, 2005 1994년 WTO의 탄생으로 세계는 국제통상에 있어 法의 支配를 실현시켜 나가 고 있다. 무역의 자유화와 확대를 통한 인류복지의 증진과 공정무역의 실현을 위 한 정의로운 競爭規則의 정립을 향하여 나아가고 있는 것이다. 통상과 관련하여 인류에게 다가오는 새로운 의제에 대한 논의(소위 New Round) 역시 WTO 및 OECD를 중심으로 한 세계 각국의 지혜가 요구된다.
Kim, Kiyoung
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
QUINE, DOGALLAŞTIRILMIŞ EPİSTEMOLOJİ VE EPİSTEMOLOJİNİN NORMATİF YÖNÜ
Felsefe Dünyası, 2007 QUINE, DOGALLAŞTIRILMIŞ EPİSTEMOLOJİ VE EPİSTEMOLOJİNİN NORMATİF ...
Fatih Sultan Mehmet Öztürk
doaj
AN IMPROVED SURVEILLANCE SYSTEM ARCHITECTURE BASED ON FLAME DETECTION IN CCTVS
ICTACT Journal on Image and Video Processing, 2018 CCTV is an important part of the surveillance systems. While a person observes the screens with the naked eye in existing CCTV monitoring systems, it is possible that the flame and events are not detected opportunely due to eye fatigue and human ...
ChangYong Ri +3 more
doaj +1 more source
A Network of Argumentation Schemes and Critical Questions
Informal Logic, 2022 In this paper, we devise a network that consists of argumentation schemes and critical questions that participants in debates can use to easily construct arguments that attack or support former arguments.
Sung-Jun Pyon, Yong-Sok Ri
doaj +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
بهداشت کار و ارتقای سلامت, 2019 Introduction: Manual handling expose workers force, awkward postures, and repetitive motions. The aim of the present study was the assessment of lifting capacity by the KIM and NIOSH equation methods.
Fatemeh ROSTAMI, Mehdi HOJATI
doaj
Quantum consistency in supersymmetric theories with R-symmetry in curved space
Journal of High Energy Physics, 2019 We discuss consistency at the quantum level in the rigid N $$ \mathcal{N} $$ = 1 supersymmetric field theories with a U(1) R symmetry in four-dimensional curved space which are formulated via coupling to the new-minimal supergravity background fields. By
Ok Song An +3 more
doaj +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source