Results 51 to 60 of about 228,203 (285)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Sakarya Tıp Dergisi, 2021 Amaç Akut miyokard infarktüsü nedeni ile perkütan koroner girişim yapılan hastalarda, kontrast madde hacminin glomerüler filtrasyon hızına oranının (KV/GFH) kontrast ilişkili nefropatiyi (KİN) öngördürmedeki etkisini belirlemek ve KİN gelişiminden ...
Ümmü Taş +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Multicultural Shakespeare, 2017 This article shows how the language of Shakespeare’s plays has been rendered into Catalan in three especially significant periods: the late 19th century, the early 20th century, and the late 20th and early 21st centuries. The first section centres on the
Dídac Pujol
doaj +1 more source
Plants, 2023 In the natural environment, plants grow and interact with both conspecific and heterospecific neighbours under different environmental conditions. In this study, we tested whether Chenopodium quinoa Willd genotypes differ in growth performance when grown
Jan Sher +5 more
doaj +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
Horizontes Antropológicos, 2010 Por meio de uma análise de redações de crianças fijianas sobre o futuro, este artigo examina ideias de socialidade, pessoalidade e self que constituem a matéria mesmo da intersubjetividade e, portanto, da imaginação.
Christina Toren
doaj +1 more source
Kin-Mediated Male Choice and Alternative Reproductive Tactics in Spider Mites
Biology, 2020 Optimal outbreeding and kin selection theories state that the degree of kinship is a fundamental determinant in any mating system. However, the role of kinship in male choice and alternative reproductive tactics (ARTs) is poorly known.
Peter Schausberger, Yukie Sato
doaj +1 more source
Frontiers in Plant Science, 2022 Kin recognition might help plants decrease competitive cost and improve inclusive fitness with close genes; thus it might interact with environmental factors to affect communities.
Yilei Fan +3 more
doaj +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source