Results 101 to 110 of about 1,883,043 (318)

Regulation der humanen Aurora-A Kinase und Identifikation potentieller Interaktionspartner [PDF]

, 2004
The error-free segregation of duplicated chromosomes during cell division is essential for the maintenance of an intact genome. This process is brought about by a highly dynamic bipolar array of microtubules, the mitotic spindle.
Kufer, Thomas
core  

Functional analysis of the "Saccharomyces cerevisiae" Npr1 protein kinase [PDF]

, 2007
The uptake and processing of nutrients is highly regulated. Cells adapt to changes of the availability of nutrients to provide a complete set of transporters and metabolizing enzymes for optimal use of the available nutrients.
Gander, Stefan
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts

, 2004
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence ...
Abraham, DJ, du Bois, R M, Denton, CP, Black, C M, Chen, YL, Chen, Y L, Chen, Y, Shi-Wen, X., Renzoni, E.A., Denton, C P, Shi-Wen, X, Leask, A., Pearson, J D, Xu, SW, Bou-Gharios, George, du Bois, RM, Xu, S W, Dashwood, M, Denton, C.P., Bou-Gharios, G., Renzoni, E A, Pearson, JD, Chen, Y., Abraham, D.J., Abraham, D J, Renzoni, EA, Black, CM, Dashwood, M., Eastwood, M, Leask, A, Eastwood, M., Black, C.M., Pearson, J., du Bois, R., Bou-Gharios, G   +34 more
core   +1 more source

The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells [PDF]

, 2012
Phytopathogenic oomycetes, such as Phytophthora infestans, secrete an arsenal of effector proteins that modulate plant innate immunity to enable infection. We describe CRN8, a host-translocated effector of P. infestans that has kinase activity in planta.
Cakir, Cahid, Tolga O Bozkurt, Sebastian Schornack, Cahid Cakir, Mireille van Damme, Cahid Cakir (142118), Bozkurt, Tolga O, Kamoun, S., Kamoun, Sophien, van Damme, M., Jones, A.M.E., Sklenar, Jan, Sophien Kamoun (6132), Cakir, C., Schornack, S., Schornack, Sebastian, van Damme, Mireille, Jan Sklenar (142122), Jones, Alexandra ME, Jones, Alexandra M., Mireille van Damme (142110), Tolga O. Bozkurt (142114), Bozkurt, Tolga O., Sophien Kamoun, Bozkurt, T.O., Sklenar, J., Alexandra M. E. Jones (50010), Alexandra M E Jones, Damme, M., van, Sebastian Schornack (142120), Jan Sklenar   +30 more
core   +1 more source

Heart failure induced by perinatal ablation of cardiac myosin light chain kinase

Frontiers in Physiology, 2016
Background: Germline knockout mice are invaluable in understanding the function of the targeted genes. Sometimes, however, unexpected phenotypes are encountered, due in part to the activation of compensatory mechanisms.
Yasmin F. K. Islam, Ryan Joseph, Rajib Chowdhury, Robert Henry Anderson, Hideko Kasahara   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts. [PDF]

, 1995
Activation of p34cdc2 kinase is essential for entry into mitosis while subsequent deactivation and cyclin degradation are associated with exit. In Xenopus embryos, both of these phases are regulated by post-translational modifications and occur ...
Whitaker, Michael J., Lindsay, Howard D., Ford, Christopher C.   +2 more
core