Results 61 to 70 of about 854,863 (214)

Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma

Journal of Asthma and Allergy, 2008
Jing Ying Ma1, Satyanarayana Medicherla1, Irene Kerr, Ruban Mangadu, Andrew A Protter, Linda S Higgins1Scios Inc, Fremont, CA, USA 1Jing Ying Ma and Satyanarayana Medicherla contributed equally to this workAbstract: p38 Mitogen-activated protein kinase ...
Jing Ying Ma, Satyanarayana Medicherla, Irene Kerr, Ruban Mangadu, Andrew A Protter, Linda S Higgins   +5 more
doaj  

Cigarette Smoke Exposure Leads to Organic and Mineral Bone Component Changes: The Importance of Rho Kinase Function in These Events

Cells
Aberrant Rho-associated kinase function could be associated with increased bone fragility. Since cigarette smoke (CS) exposure promotes the increase in bone fragility due to changes in bone tissue components, this study aimed to investigate how CS ...
Alex Ferreira da Silva, Franciele Jesus Lima, Alyne Riani Moreira, Cintia do Nascimento Silva, Ivone Braga de Oliveira, Alexandra Fernandes Callera, Ana Luiza Porfirio, Luan Henrique Vasconcelos Alves, Iolanda de Fátima Lopes Calvo Tibério, Ana Paula Pereira Velosa, Vanda Jorgetti, Walcy Rosolia Teodoro, Fernanda Degobbi Tibério Quirino Dos Santos Lopes   +12 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation

Therapeutic Advances in Respiratory Disease, 2020
Background and aims: Expansion and morphological dysregulation of the bronchial vascular network occurs in asthmatic airways. Interleukin (IL) -17 and Rho-kinase (ROCK) are known to act in inflammation control and remodeling.
Tabata M. dos Santos, Renato F. Righetti, Bianca G. Rezende, Elaine C. Campos, Leandro do N. Camargo, Beatriz M. Saraiva-Romanholo, Silvia Fukuzaki, Carla M. Prado, Edna A. Leick, Milton A. Martins, Iolanda F. L. C. Tibério   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

In vitro and in silico modelling of ROS1-positive non-small cell lung cancer reveals fusion-dependent tyrosine kinase inhibitor responses. [PDF]

Mol Oncol
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Ul Haq F, Terrones M, Rodrigues Fortes F, Schepers A, Denis A, Deben C, Op de Beeck K, Van Camp G, Vandeweyer G.   +8 more
europepmc   +2 more sources

Enhancing kinase-inhibitor activity and selectivity prediction through contrastive learning

Nature Communications
Developing selective kinase inhibitors is challenging due to the conserved kinase structures and costly kinome profiling experiments, highlighting the need for accurate prediction of kinase-inhibitor affinity and specificity.
Yanan Tian, Ruiqiang Lu, Xiaoqing Gong, Wei Zhao, Yuquan Li, Xiaorui Wang, Xinming Jia, Qin Li, Yuwei Yang, Henry H. Y. Tong, Joel P. Arrais, Xiaojun Yao, Huanxiang Liu   +12 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Advances in multi-scale computational approaches for kinase selectivity profiling [PDF]

Digital Discovery
Protein kinases represent a major class of therapeutic targets; however, achieving high selectivity remains a fundamental challenge due to the high structural homology of the adenosine triphosphate (ATP)-binding pocket, which predisposes most inhibitors ...
Li Qin, Yanan Tian, Shukai Gu, Silong Zhai, Huanxiang Liu, Xiaojun Yao   +5 more
doaj   +1 more source