Results 311 to 320 of about 4,906,436 (344)

Deep learning enables rapid identification of potent DDR1 kinase inhibitors

Nature Biotechnology, 2019
A. Zhavoronkov, Y. Ivanenkov, Alex Aliper, M. Veselov, V. Aladinskiy, Anastasiya V Aladinskaya, V. Terentiev, Daniil Polykovskiy, Maksim Kuznetsov, Arip Asadulaev, Yury Volkov, Artem Zholus, Shayakhmetov Rim, Alexander Zhebrak, L. Minaeva, B. Zagribelnyy, L. Lee, R. Soll, D. Madge, Li Xing, Tao Guo, Alán Aspuru-Guzik   +21 more
semanticscholar   +1 more source

Specificity and mechanism of action of some commonly used protein kinase inhibitors.

Biochemical Journal, 2000
S. Davies, Helen Reddy, M. Caivano, P. Cohen   +3 more
semanticscholar   +1 more source

Design of kinase inhibitors

Medicinal Research Reviews, 1987
G L, Kenyon, G A, Garcia
openaire   +2 more sources

Inhibitors of protein kinases

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
David, Shugar, Doriano, Fabbro
openaire   +2 more sources

Therapeutic Protein Kinase Inhibitors

Cellular and Molecular Life Sciences, 2008
Protein kinase inhibitors represent an important and still emerging class of targeted therapeutic agents. Drug discovery and development strategies have explored numerous approaches to target the inhibition of protein kinase signaling. This review will highlight some of the strategies that have led to the successful clinical development of therapeutic ...
openaire   +2 more sources

Kinases and kinase inhibitors

2020
Graham L. Patrick, Helen Turner
openaire   +1 more source

Kinase Inhibitors in Leukemia

2004
Mark, Levis, Donald, Small
openaire   +2 more sources

Kinase inhibitors and airway inflammation.

European journal of pharmacology, 2006
Kinases are believed to play a crucial role in the expression and activation of inflammatory mediators in the airway, in T-cell function and airway remodelling. Important kinases such as Inhibitor of kappaB kinase (IKK)2, mitogen activated protein (MAP) kinases and phsopho-inositol (PI)3 kinase regulate inflammation either through activation of pro ...
ADCOCK IM, CHUNG KF, CARAMORI, Gaetano, ITO K.   +3 more
openaire   +3 more sources

[Kinase inhibitors].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2008
Masatoshi, Hagiwara, Hirokazu, Usuki
openaire   +3 more sources

New Promise and Opportunities for Allosteric Kinase Inhibitors

Angewandte Chemie - International Edition, 2020
Xiaoyun Lu, Jeffrey Smaill, Ke Ding
exaly