Results 51 to 60 of about 4,906,436 (344)

Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]

, 2017
The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert, Janetka, James, Klampfer, Lidija, Owusu, Benjamin Yaw   +3 more
core   +2 more sources

Experimental and clinical tests of FDA-approved kinase inhibitors for the treatment of neurological disorders (update 2024) [PDF]

Exploration of Drug Science
Since our previous summary of the 74 FDA-approved kinase inhibitors in clinical and preclinical trials for non-cancerous neurological treatment, the US FDA has approved 13 additional kinase inhibitors since early 2022.
Hassan Aliashrafzadeh, Dewey Liu, Samantha De Alba, Imad Akbar, Austin Lui, Jordan Vanleuven, Ryan Martin, Zhang Wang, Da Zhi Liu   +8 more
doaj   +1 more source

Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting

eLife, 2023
Kinase inhibitors are successful therapeutics in the treatment of cancers and autoimmune diseases and are useful tools in biomedical research. However, the high sequence and structural conservation of the catalytic kinase domain complicate the ...
Ian R Outhwaite, Sukrit Singh, Benedict-Tilman Berger, Stefan Knapp, John D Chodera, Markus A Seeliger   +5 more
doaj   +1 more source

Efficacy of temsirolimus in metastatic chromophobe renal cell carcinoma [PDF]

, 2013
<p>Background: Renal cell carcinoma (RCC) is a histopathologically and molecularly heterogeneous disease with the chromophobe subtype (chRCC) accounting for approximately 5% of all cases.
A Armstrong, A Jemal, B Paule, B Shuch, Balaji Venugopal, D Zardavas, G Hudes, G Kovacs, J Dutcher, J-J Patard, Jawaher Ansari, JMG Larkin, Lye Mun Tho, ME Gore, Michael Aitchison, PH Patel, RJ Motzer, RJ Motzer, Rob J Jones, Roderick Campbell, SK Tickoo, TK Choueiri   +21 more
core   +1 more source

QTC Changes Associated with Tyrosine Kinase Inhibitors in Cancer Patients

Pakistan Armed Forces Medical Journal, 2022
Objective: To look for QTc changes associated with Tyrosine Kinase inhibitors and factors related to these changes among patients suffering from cancer. Study Design: Comparative cross-sectional study.
Rahimullah Khattak, Riaz Ahmad, Muhammad Nadeem, Huma Amjad, Amjad Khan, Ibtisam .   +5 more
doaj   +1 more source

Targeting RTK signaling pathways in cancer [PDF]

, 2015
The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding.
Regad, T
core   +1 more source

Imatinib resistance: a review of alternative inhibitors in chronic myeloid leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2011
The development of point mutations in the BCR-ABL kinase domain is the main reason for imatinib resistance in chronic myeloid leukemia. Different detection methods are used in chronic myeloid leukemia monitoring, such as direct sequencing, denaturing ...
Roberta Bitencourt, Ilana Zalcberg, Iúri Drumond Louro   +2 more
doaj   +1 more source

Efficacy of Next-Generation EGFR-TKIs in Patients With Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials

Technology in Cancer Research & Treatment, 2020
Background: The efficacy of next-generation epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer who have failed first-generation epidermal growth factor receptor-tyrosine kinase inhibitors ...
Yi-Tian Qi MM, Yi Hou PhD, Liang-Chen Qi MD   +2 more
doaj   +1 more source

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources

Inhibitor Trapping in Kinases

International Journal of Molecular Sciences
Recently, we identified a novel mechanism of enzyme inhibition in N-myristoyltransferases (NMTs), which we have named ‘inhibitor trapping’. Inhibitor trapping occurs when the protein captures the small molecule within its structural confines, thereby preventing its free dissociation and resulting in a dramatic increase in inhibitor affinity and potency.
Danislav S. Spassov, Mariyana Atanasova, Irini Doytchinova   +2 more
openaire   +2 more sources