Results 121 to 130 of about 1,477,881 (298)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

Cell, 2007
K. Rikova, A. Guo, Q. Zeng, A. Possemato, Jian Yu, H. Haack, J. Nardone, Kimberly A. Lee, C. Reeves, Y. Li, Yerong Hu, Zhiping Tan, M. Stokes, Laura A. Sullivan, Jeffrey Mitchell, Randy Wetzel, Joan Macneill, J. Ren, Jin Yuan, C. Bakalarski, J. Villén, J. Kornhauser, Bradley L. Smith, Dai-qiang Li, Xinmin Zhou, S. Gygi, T. Gu, R. Polakiewicz, J. Rush, M. Comb   +29 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions. [PDF]

Nat Commun
Garrido-Rodriguez M, Potel C, Burtscher ML, Becher I, Rodriguez-Mier P, Müller-Dott S, Savitski MM, Saez-Rodriguez J.   +7 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Characterization of the TREM-1 signaling landscape in human neutrophils. [PDF]

PLoS One
Ries F, Klein M, Rogmann N, Többen S, Marini F, Heidel F, Radsak MP.   +6 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Cellular Context Influences Kinase Inhibitor Selectivity. [PDF]

J Med Chem
Binder MJ, Bashore FM, Dunn Hoffman KK, Damgaard C, Slater M, Drewry DH, Robers MB, Axtman AD.   +7 more
europepmc   +1 more source