Results 141 to 150 of about 147,757 (263)

Representing and Quantifying Conformational Changes of Kinases and Phosphatases Using the TSR-Based Algorithm

Kinases and Phosphatases
Protein kinases and phosphatases are key signaling proteins and are important drug targets. An explosion in the number of publicly available 3D structures of proteins has been seen in recent years.
Tarikul I. Milon, Krishna Rauniyar, Sara Furman, Khairum H. Orthi, Yingchun Wang, Vijay Raghavan, Wu Xu   +6 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Novel roles for the MAPK-interacting serine threonine kinases (Mnks)

, 2013
The mitogen activated protein kinase (MAPK)-interacting serine threonine kinases (Mnks) are components of the MEK/ERK and p38MAPK signalling pathways.
Stead, Rebecca
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Kinases involved in the angiotensin signalling pathway.

, 2014
A comparison of the kinases phosphorylated in Christensen et al., 2010 and Xiao et al., 2010, with an overlay of the NetworKIN predicted active kinases.
Gitte L. Christensen (550188), Rikke Bøgebo (6879), Jesper V. Olsen (23892), Lars J. Jensen (5538), Jakob L. Hansen (550187), Heiko Horn (550186), Steen Gammeltoft (6880)   +6 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Classification of the Microsporidian Protein Kinases.

, 2014
150 kinases were classified into groups, families and subfamilies. The cell cycle-related families are labeled in bold italic typeface.Classification of the Microsporidian Protein Kinases.
Heng Xiang (679982), Zeyang Zhou (57647), Zhi Li (72309), Youjin Hao (5661802), Linling Wang (679981)   +4 more
core   +1 more source

“Hydroxylamine Kinase” and Pyruvic Kinase

Journal of Biological Chemistry, 1960
F P, KUPIECKI, M J, COON
openaire   +2 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Signal Transduction: Switching off MAP kinases

, 1994
Protein phosphatases have recently been identified that inactivate MAP kinases and turn off intracellular signalling pathways. Their regulation may determine the response of cells to stimuli that signal via MAP kinases.
Clarke, P.R., Clarke, Paul R.
core   +1 more source