Results 11 to 20 of about 1,477,881 (298)

Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies

Biomolecules, 2022
Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in ...
Said Moshawih, Ai Fern Lim, Chrismawan Ardianto, Khang Wen Goh, Nurolaini Kifli, Hui Poh Goh, Qais Jarrar, Long Chiau Ming   +7 more
doaj   +1 more source

Author Correction: YAP1/TAZ drives ependymoma-like tumour formation in mice

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Noreen Eder, Federico Roncaroli, Marie-Charlotte Domart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Jun-Hao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, Sila K. Ultanir   +14 more
doaj   +1 more source

Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance in Arabidopsis

Frontiers in Plant Science, 2023
IntroductionReceptor-like cytoplastic kinases (RLCKs) are known in many plants to be involved in various processes of plant growth and development and regulate plant immunity to pathogen infection.
Jinlan Fang, Jinlan Fang, Zhe Chai, Zhe Chai, Run Huang, Cuilin Huang, Zhenhua Ming, Baoshan Chen, Wei Yao, Wei Yao, Muqing Zhang, Muqing Zhang   +11 more
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YAP1/TAZ drives ependymoma-like tumour formation in mice

Nature Communications, 2020
YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.
Noreen Eder, Federico Roncaroli, Marie-Charlotte Domart, Stuart Horswell, Felipe Andreiuolo, Helen R. Flynn, Andre T. Lopes, Suzanne Claxton, John-Paul Kilday, Lucy Collinson, Jun-Hao Mao, Torsten Pietsch, Barry Thompson, Ambrosius P. Snijders, Sila K. Ultanir   +14 more
doaj   +1 more source

Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases

Viruses, 2023
Despite the great technological and medical advances in fighting viral diseases, new therapies for most of them are still lacking, and existing antivirals suffer from major limitations regarding drug resistance and a limited spectrum of activity. In fact,
Rima Hajjo, Dima A. Sabbah, Osama H. Abusara, Reham Kharmah, Sanaa Bardaweel   +4 more
doaj   +1 more source

δ-Opioid Receptor as a Molecular Target for Increasing Cardiac Resistance to Reperfusion in Drug Development

Biomedicines, 2023
An analysis of published data and the results of our own studies reveal that the activation of a peripheral δ2-opioid receptor (δ2-OR) increases the cardiac tolerance to reperfusion.
Natalia V. Naryzhnaya, Alexander V. Mukhomedzyanov, Maria Sirotina, Leonid N. Maslov, Boris K. Kurbatov, Alexander S. Gorbunov, Mikhail Kilin, Artur Kan, Andrey V. Krylatov, Yuri K. Podoksenov, Sergey V. Logvinov   +10 more
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A Chemical Proteomics Approach to Discover Regulators of Innate Immune Signaling

Viruses, 2023
Innate immune pathways are tightly regulated to balance an appropriate response to infectious agents and tolerable levels of inflammation. Dysregulation of innate immune pathways can lead to severe autoinflammatory disorders or susceptibility to ...
Andrew P. Kurland, Boris Bonaventure, Jeffrey R. Johnson   +2 more
doaj   +1 more source

An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors

Molecules, 2020
Malaria control relies heavily on the small number of existing antimalarial drugs. However, recurring antimalarial drug resistance necessitates the continual generation of new antimalarial drugs with novel modes of action.
Chantalle Moolman, Rencia van der Sluis, Richard M. Beteck, Lesetja J. Legoabe   +3 more
doaj   +1 more source

Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease

Viruses, 2023
Zoonotic pathogens that are vector-transmitted have and continue to contribute to several emerging infections globally. In recent years, spillover events of such zoonotic pathogens have increased in frequency as a result of direct contact with livestock,
Carol Anderson, Haseebullah Baha, Niloufar Boghdeh, Michael Barrera, Farhang Alem, Aarthi Narayanan   +5 more
doaj   +1 more source

Inhibitors of mammalian G1 cyclin-dependent kinases.

Genes & Development, 1995
Biologic machines need brakes, and the nature and fidelity of their operation cannot be unraveled without some prior understanding of how accelerators work. The discoveD] of mammalian G1 cyclins just 4 years ago and the identification of their associated
C. Sherr, James M. Roberts
semanticscholar   +1 more source