Results 241 to 250 of about 1,477,881 (298)

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

Frontiers in Bioscience, 2008
The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP
Buxade, Maria, Parra-Palau, Josep L., Proud, Christopher G.   +2 more
openaire   +3 more sources

Phosphatidylinositol 3-kinase related kinases

Current Opinion in Immunology, 1996
Studies in yeast, files and mammalian cells have uncovered a novel family of signal-transducing kinases which bear an evolutionary relationship to phosphatidylinositol 3-kinase. These phosphatidylinositol 3-kinase related enzymes play critical roles in DNA repair, V(D)J recombination and cell-cycle checkpoints, and their dysfunction leads to clinical ...
openaire   +2 more sources

Kinase dysfunction and kinase inhibitors

Veterinary Dermatology, 2013
With recent advances in molecular biology, abnormalities in cancer cells that contribute to dysregulation of cell survival and proliferation are being characterized with greater precision. Through this process, key abnormalities in cancer cells involving proteins that regulate signal transduction, migration, mitosis and other critical processes have ...
openaire   +2 more sources

Cyclin dependent kinase activating kinases

Current Opinion in Cell Biology, 1996
The cyclin dependent kinase activating kinase (CAK) has roles in both cell cycle regulation and transcription. CAK assembly is regulated either by additional protein binding or by phosphorylation. A recent comparison of this kinase from two yeast species shows that different proteins perform distinct roles and that the most studied CAK may function ...
openaire   +2 more sources

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Science, 1995
Z. Xia, M. Dickens, J. Raingeaud, R. Davis, M. Greenberg   +4 more
semanticscholar   +1 more source

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Science, 2002
G. Johnson, R. Lapadat
semanticscholar   +1 more source

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Nature reviews genetics, 2006
J. Engelman, Ji Luo, L. Cantley
semanticscholar   +1 more source

p21 is a universal inhibitor of cyclin kinases

Nature, 1993
Y. Xiong, G. Hannon, Hui Zhang, D. Casso, R. Kobayashi, D. Beach   +5 more
semanticscholar   +1 more source

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Science, 2000
F. Urano, Xiaozhong Wang, A. Bertolotti, Yuhong Zhang, Peter Chung, H. Harding, D. Ron   +6 more
semanticscholar   +1 more source

ATM and related protein kinases: safeguarding genome integrity

Nature Reviews. Cancer, 2003
Y. Shiloh
semanticscholar   +1 more source