Results 221 to 230 of about 147,757 (263)

Kinase Inhibitors:  Not Just for Kinases Anymore

Journal of Medicinal Chemistry, 2003
Kinase inhibitors are widely employed as biological reagents and as leads for drug design. Their use is often complicated by their lack of specificity. Although binding conserved ATP sites accounts for some of their nonspecificity, some compounds inhibit proteins not known to bind ATP.
Susan L, McGovern, Brian K, Shoichet
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NAK is an IκB kinase-activating kinase

Nature, 2000
Phosphorylation of IkappaB by the IkappaB kinase (IKK) complex is a critical step leading to IkappaB degradation and activation of transcription factor NF-kappaB. The IKK complex contains two catalytic subunits, IKKalpha and IKKbeta, the latter being indispensable for NF-kappaB activation by pro-inflammatory cytokines.
Y, Tojima, A, Fujimoto, M, Delhase, Y, Chen, S, Hatakeyama, K, Nakayama, Y, Kaneko, Y, Nimura, N, Motoyama, K, Ikeda, M, Karin, M, Nakanishi   +11 more
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Phosphatidylinositol 3-kinase related kinases

Current Opinion in Immunology, 1996
Studies in yeast, files and mammalian cells have uncovered a novel family of signal-transducing kinases which bear an evolutionary relationship to phosphatidylinositol 3-kinase. These phosphatidylinositol 3-kinase related enzymes play critical roles in DNA repair, V(D)J recombination and cell-cycle checkpoints, and their dysfunction leads to clinical ...
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Cyclin dependent kinase activating kinases

Current Opinion in Cell Biology, 1996
The cyclin dependent kinase activating kinase (CAK) has roles in both cell cycle regulation and transcription. CAK assembly is regulated either by additional protein binding or by phosphorylation. A recent comparison of this kinase from two yeast species shows that different proteins perform distinct roles and that the most studied CAK may function ...
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Kinase Drug Discovery 20 Years After Imatinib

Nature Reviews Drug Discovery, 2022
Philip Cohen, Pasi A Ja Nne
exaly  

MAP Kinase Kinase Kinase Kinase (MAPKKKK)

2008
openaire   +1 more source

MKKK (MAP Kinase Kinase Kinase)

2012
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Kinase Inhibitors: The Road Ahead

Nature Reviews Drug Discovery, 2018
Nathanael Gray, Fleur M Ferguson
exaly  

MAP Kinase Kinase Kinase (MAPKKK)

2008
openaire   +1 more source

Kinases and kinase inhibitors

2020
Graham L. Patrick, Helen Turner
openaire   +1 more source