Results 231 to 240 of about 595,423 (308)

Preparing for pharmacy-based delivery of long-acting injectable antiretrovirals: a pre-implementation study. [PDF]

BMC Health Serv Res
Cocohoba J, Cuca Y, Sherman E, Hester K, Udeani G, Sigua M, Saberi P.   +6 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Epidemiological trends of depression and anxiety at global, regional, and national level: A population-based observational study from 1990 to 2021 based on Global Burden of Disease 2021. [PDF]

Medicine (Baltimore)
Chen M, Wang Y, Tan C.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Welfare policy and suicide: The role of "supporting the self-reliance of persons in need" program in Japan. [PDF]

SSM Popul Health
Zuo X.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

General practitioners' perspectives on blood biomarkers for Alzheimer's disease. [PDF]

Alzheimers Dement (Amst)
Claessen T, Visser FCW, van Munster BC, van der Flier WM, Jiménez-Mausbach M, van Harten AC, Teunissen CE, Visser LNC.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Five New Principles to Govern Intersex Pediatric Surgery: A Reply to Kevin G. Behrens. [PDF]

Linacre Q
Rehman R.
europepmc   +1 more source

The Sanctity of Life, the Quality of Life and the New \u27Baby Doe\u27 Law [PDF]

, 1985
Johnstone, Brian V.
core   +1 more source