Binaural acoustic stimulation in patients with Parkinson’s disease [PDF]
Frontiers in Neurology, 2023 Acoustic stimulation can improve motor symptoms in Parkinson’s disease (PD) and might therefore represent a potential non-invasive treatment option.
Alexander Calvano +7 more
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Effects of Immediate Aversive Stimulation on Haloperidol-Induced Catalepsy in Rats [PDF]
Frontiers in Behavioral Neuroscience, 2022 In animal models, the administration of the dopaminergic D2 antagonist haloperidol affects the nigrostriatal pathway, inducing catalepsy, a state of immobility similar to Parkinson’s disease (PD) bradykinesia and akinesia.
Isabelle Waku +4 more
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Commercial symptom monitoring devices in Parkinson’s disease: benefits, limitations, and trends [PDF]
Frontiers in NeurologyParkinson’s disease (PD) is a neurodegenerative disorder that significantly impacts patients’ quality of life. Managing PD requires accurate assessment of motor and non-motor symptoms, often complicated by the subjectivity in symptom reporting and the ...
Daniel Rodríguez-Martín +2 more
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Paradoxical Kinesia Induced by Nightmare: Unique Case Report and Insights regarding the Neural Mechanism Based on Human and Rat Studies [PDF]
Case Reports in NeurologyIntroduction: Bradykinesia, characterized by slowed movement, stands out as a primary symptom observed in individuals with Parkinson’s disease (PD). Nonetheless, there are instances where PD patients exhibit sudden and effective movements despite the ...
Jorge Gelvane Tostes +5 more
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Optogenetic stimulation of inferior colliculus neurons elicits mesencephalic locomotor region activity and reverses haloperidol-induced catalepsy in rats [PDF]
Scientific ReportsThe inferior colliculus (IC) represents a pivotal midbrain area involved in processing sensory/emotional facets of auditory stimuli, potentially influencing motor responses.
José A. Pochapski +7 more
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Health Technology AssessmentBackground Parkinson’s disease is a brain condition causing a progressive loss of co ordination and movement problems. Around 145,500 people have Parkinson’s disease in the United Kingdom.
Edward Cox +8 more
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Assessing Changes in Motor Function and Mobility in Individuals with Parkinson’s Disease After 12 Sessions of Patient-Specific Adaptive Dynamic Cycling [PDF]
SensorsBackground and Purpose: This pilot randomized controlled trial evaluated the effects of 12 sessions of patient-specific adaptive dynamic cycling (PSADC) versus non-adaptive cycling (NA) on motor function and mobility in individuals with Parkinson’s ...
Younguk Kim +5 more
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Differential Responses to Low- and High-Frequency Subthalamic Nucleus Deep Brain Stimulation on Sensor-Measured Components of Bradykinesia in Parkinson’s Disease [PDF]
SensorsIntroduction: The current approach to assessing bradykinesia in Parkinson’s Disease relies on the Unified Parkinson’s Disease Rating Scale (UPDRS), which is a numeric scale. Inertial sensors offer the ability to probe subcomponents of bradykinesia: motor
Akash Mishra +5 more
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Low frequency deep brain stimulation in the inferior colliculus ameliorates haloperidol-induced catalepsy and reduces anxiety in rats. [PDF]
PLoS ONE, 2020 Deep brain stimulation (DBS) of the colliculus inferior (IC) improves haloperidol-induced catalepsy and induces paradoxal kinesia in rats. Since the IC is part of the brain aversive system, DBS of this structure has long been related to aversive behavior
Hannah Ihme +2 more
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Developing and assessing a new web-based tapping test for measuring distal movement in Parkinson’s disease: a Distal Finger Tapping test [PDF]
Scientific Reports, 2022 Disability in Parkinson’s disease (PD) is measured by standardised scales including the MDS-UPDRS, which are subject to high inter and intra-rater variability and fail to capture subtle motor impairment.
Noreen Akram +8 more
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