Results 21 to 30 of about 2,969 (177)
A Phase 2 Proof‐of‐Concept, Randomized, Placebo‐Controlled Trial of CX‐8998 in Essential Tremor
Movement Disorders, Volume 36, Issue 8, Page 1944-1949, August 2021., 2021 Abstract Background Available essential tremor (ET) therapies have limitations. Objectives The objective of this study was to evaluate CX‐8998, a selective T‐type calcium channel modulator, in essential tremor. Methods Patients 18–75 years old with moderate to severe essential tremor were randomized 1:1 to receive CX‐8998 (titrated to 10 mg twice daily)
Spyros Papapetropoulos +13 more
wiley +1 more source
Digitally Enabled, Patient‐Centric Clinical Trials: Shifting the Drug Development Paradigm
Clinical and Translational Science, Volume 14, Issue 2, Page 445-459, March 2021., 2021 The rapidly advancing field of digital health technologies provides a great opportunity to radically transform the way clinical trials are conducted and to shift the clinical trial paradigm from a site‐centric to a patient‐centric model. Merck’s (Kenilworth, NJ) digitally enabled clinical trial initiative is focused on introduction of digital ...
Marissa F. Dockendorf +5 more
wiley +1 more source
, 2023 Movement Disorders Clinical Practice, Volume 10, Issue S2, Page S56-S62, August 2023.
Anouk Tosserams +2 more
wiley +1 more source
El espacio de teatro en el Taller de Parkinson
Revista +E, 2015 Presentamos el espacio de teatro en el Taller de Parkinson, sus objetivos, metodología y resultados. Este taller es una iniciativa de un grupo interdisciplinario de profesionales (actualmente programa estable de extensión de la Facultad de Ciencias ...
Vanina Dubois +1 more
doaj +1 more source
Clinical Parkinsonism & Related Disorders, 2020 Background: Fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease affecting carriers of a 55–200 CGG repeat in the fragile X mental retardation 1 gene, may receive an initial diagnosis of Parkinson's disease (PD) or essential ...
Erin E. Robertson +7 more
doaj +1 more source
Single Dose of a Dopamine Agonist Impairs Reinforcement Learning in Humans: Behavioral Evidence from a Laboratory-based Measure of Reward Responsiveness [PDF]
, 2010 Rationale. The dopaminergic system, particularly D2-like dopamine receptors, has been strongly implicated in reward processing. Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes ...
Culhane, Melissa +6 more
core +1 more source
Frontiers in Neurology, 2019 Background: Essential tremor (ET) is a common, progressive neurological syndrome with bilateral upper-limb dysfunction of at least 3-year duration, with or without tremor in other body locations.
Spyros Papapetropoulos +3 more
doaj +1 more source
La comunicación kinésica en la formación inicial del maestro logopeda
Transformación, 2021 Objetivo: El artículo describe una estrategia didáctica para al tratamiento de la comunicación kinésica en la formación inicial del maestro logopeda. Métodos: Los autores emplearon métodos de investigación como el análisis, la síntesis, el histórico ...
M. Sc. Déborah Magaly López Salas +2 more
doaj +2 more sources
Duazary, 2018 Se propone analizar distintas cuestiones comportamentales que afectan la comunicación de las personas con Enfermedad de Parkinson (EP) en relación a su entorno, en función del desarrollo de una propuesta de comunicación basada en el marco de una ...
María de los Angeles Bacigalupe
doaj +1 more source
A double closed loop to enhance the quality of life of Parkinson's disease patients: REMPARK system [PDF]
, 2014 This paper presents REMPARK system, a novel approach to deal with Parkinson's Disease (PD). REMPARK system comprises two closed loops of actuation onto PD.
Ahlrichs, Claas +7 more
core +1 more source