Results 171 to 180 of about 136,664 (227)

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana   +2 more
wiley   +1 more source

Physiological Interpretation of the Lactate to Pyruvate AUC Ratio for Hyperpolarized [1‐13C]‐Pyruvate Studies

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 1, Page 247-258, July 2026.
ABSTRACT Purpose To explore the relationship between potentially rate‐limiting steps in lactate production and the lactate area‐under‐the‐curve (AUC) to pyruvate AUC ratio for analysis of hyperpolarized (HP) [1‐13C]‐pyruvate data. Theory and Methods Simplifying assumptions are introduced to a pharmacokinetic (PK) model with three physical compartments ...
Ryan T. Boyce   +6 more
wiley   +1 more source

FlowVN Trained on a Single Dataset Enables Rapid Reconstruction of Highly Accelerated 4D Flow MRI Across Multiple Sites

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 1, Page 374-386, July 2026.
ABSTRACT Purpose The aim of this study is to evaluate a deep variational network, FlowVN, for the reconstruction of heavily undersampled 4D Flow MRI across multiple sites. Methods FlowVN was trained on fully sampled 4D Flow MRI datasets of healthy volunteers from one site. The model was tested on retrospective undersampled data (R = 6–22) of six normal
Sohaib Ayaz Qazi   +6 more
wiley   +1 more source

Motion‐Compensated Diffusion Imaging With Phase‐Contrast for Robust Quantification of Regional Cerebral Blood Flow

open access: yesMagnetic Resonance in Medicine, Volume 96, Issue 1, Page 238-246, July 2026.
ABSTRACT Purpose To develop and evaluate a motion‐compensated diffusion imaging with phase‐contrast (MC‐DIP) technique for mitigating errors in regional cerebral blood flow (rCBF) quantification caused by physiological brain motion. Methods Diffusion‐weighted images were acquired in 11 healthy volunteers on a 3.0 T MRI system using three gradient ...
Naoki Ohno   +6 more
wiley   +1 more source

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