Results 31 to 40 of about 94,804 (218)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Modeling Non-Equilibrium Rarefied Gas Flows Past a Cross-Domain Reentry Unmanned Flight Vehicle Using a Hybrid Macro-/Mesoscopic Scheme

Drones
The cross-domain reentry unmanned flight vehicle passes through thin atmospheres and dense atmospheres when it comes across atmospheres in the near-space area.
Weiqi Yang, Jing Men, Bowen Xu, Haixia Ding, Jie Li   +4 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Fokker–Planck Model-Based Central Moment Lattice Boltzmann Method for Effective Simulations of Thermal Convective Flows

Energies
The Fokker–Planck (FP) equation represents the drift and diffusive processes in kinetic models. It can also be regarded as a model for the collision integral of the Boltzmann-type equation to represent thermo-hydrodynamic processes in fluids. The lattice
William Schupbach, Kannan Premnath
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Kinetic theory of discontinuous shear thickening

EPJ Web of Conferences, 2017
A simple kinetic theory to exhibit a discontinuous shear thickening (DST) is proposed. The model includes a collision integral, a drag from environment and an environmental temperature Tex as well as a shear term.
Hayakawa Hisao, Takada Satoshi
doaj   +1 more source

Experimental Validation of a Sliding Mode Control for a Stewart Platform Used in Aerospace Inspection Applications

Mathematics, 2020
The authors introduce a new controller, aimed at industrial domains, that improves the performance and accuracy of positioning systems based on Stewart platforms.
Javier Velasco, Isidro Calvo, Oscar Barambones, Pablo Venegas, Cristian Napole   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Radiation Problems Accompanying Carrier Production by an Electric Field in the Graphene

Universe, 2020
A number of physical processes that occur in a flat one-dimensional graphene structure under the action of strong time-dependent electric fields are considered.
Sergei P. Gavrilov, Dmitry M. Gitman, Vadim V. Dmitriev, Anatolii D. Panferov, Stanislav A. Smolyansky   +4 more
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source