Results 101 to 110 of about 1,262,165 (318)

Musculoskeletal Injuries, Exercise Behaviors, and Reproductive Health Are Related to Physical Fitness of Female First-Responders and Health Care Providers

Women's Health Reports
Introduction: Musculoskeletal injuries (MSKi) are the most common injury type experienced by first-responders and health care providers (HCPs), making them a significant threat to physical and mental well-being.
C. M. Edwards, J. L. Puranda, É. Miller, M. Aboudlal, N. O’Rourke, M. L. MacDonald, K. B. Adamo   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Factors affecting the kinetics of froth flotation [PDF]

, 1989
In this research work, three types of flotation models (discrete, mean rate and the gamma function models) are modified based on the relationship between mass recovery and recovery. The modified models can be used to calculate both the recovery and grade
Zhang, Jian-Gou, Zhang, J
core  

Scoping Review of the Economics of Cardiovascular Disease and the Role of Exercise in Nigeria [PDF]

Batna Journal of Medical Sciences
Background: Cardiovascular diseases (CVDs) are the leading cause of death globally and a significant driver of healthcare costs in Nigeria. Despite being preventable, CVDs continue to impose economic hardship on households and threaten national ...
Rafiu O OKUNEYE, Abdulkareem B TAIWO, Fatai A APALARA, Rofiat. O DAUDA-OLAJIDE, Halimat, I. ISMAIL-ORIRE, Emmanuel OGA, Lyilola EYITAYO   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The effects of nutritional supplementation throughout an endurance run on leucine kinetics during recovery [PDF]

, 2007
This study determined the effect of nutritional supplementation throughout endurance exercise on whole-body leucine kinetics (leucine rate of appearance [Ra], oxidation [Ox], and nonoxidative leucine disposal [NOLD]) during recovery.
Ebbeling, Cara B., Miller, Sharon L., Lamont, Linda, Gaine, P. Courtney, Rodriguez, Nancy R., Maresh, Carl M., Armstrong, Lawrence E.   +6 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effects of a health education intervention on hypertension-related knowledge, prevention and self-care practices in Nigerian retirees: a quasi-experimental study

Archives of Public Health, 2019
Background Education is vital to increasing knowledge, improving prevention and self-care practices for hypertension in older adults. This study aimed to determine the effectiveness of a health education intervention in improving hypertension (HT ...
Eyuche L. Ozoemena, Cylia N. Iweama, Olaoluwa S. Agbaje, Prince C. I. Umoke, Osmond C. Ene, Perpetua C. Ofili, Benedicta N. Agu, Charity U. Orisa, Michael Agu, Enejoh Anthony   +9 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Flow-distributed spikes for Schnakenberg kinetics [PDF]

, 2011
This is the post-print version of the final published paper. The final publication is available at link.springer.com by following the link below. Copyright @ 2011 Springer-Verlag.We study a system of reaction–diffusion–convection equations which combine ...
Winter, M, Juncheng Wei, Matthias Winter, Wei, J   +3 more
core   +1 more source