Results 41 to 50 of about 772,657 (248)

pH-Sensitive Glycyrrhizin Based Vesicles for Nifedipine Delivery

Molecules, 2021
Glycyrrhizic acid, or glycyrrhizin (GA), a major active component of licorice root, has been widely used in traditional Chinese and Japanese medicine since ancient times.
Olga Yu. Selyutina, Anna V. Mastova, Ekaterina A. Shelepova, Nikolay E. Polyakov   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Increased Free Radical Generation during the Interaction of a Quinone-Quinoline Chelator with Metal Ions and the Enhancing Effect of Light

Pharmaceuticals, 2023
Schiff bases and similar molecules forming metal complexes may cause redox effects, which may also be influenced by light. Anthraquinones such as doxorubicin and idarubicin are widely used antitumor agents, which can generate reactive oxygen species (ROS)
Olga Yu. Selyutina, Simon V. Babenko, Irina A. Slepneva, Nikolay E. Polyakov, George J. Kontoghiorghes   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Development and pilot evaluation of a pregnancy-specific mobile health tool: a qualitative investigation of SmartMoms Canada

BMC Medical Informatics and Decision Making, 2018
Background Mobile technology is ubiquitous. Women of childbearing age have embraced health information technology for pregnancy-related counsel as prenatal care provider communication is increasingly scarce and brief. Pregnant women and new mothers place
Lyra Halili, Rebecca Liu, Kelly Ann Hutchinson, Kevin Semeniuk, Leanne M. Redman, Kristi B. Adamo   +5 more
doaj   +1 more source

Maternal Environmental Factors as Predictors of Occurrence of Gastroenteritis among Under - five Children in Akure South Local Government Area, Ondo State

Southeastern European Medical Journal, 2021
Aim: To examine maternal environmental factors as predictors of the incidence of gastroenteritis among under-five children in Akure South Local Government Area, Ondo State.
Oluwaseyi Oye Olofintuyi, B O Ogundele, Olasunkanmi Rowland Adeleke, Joseph Sunday Adegboro, Rachael Seun Oluwadare   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Flame Speciation and Laminar Burning Velocity of Tetralin Flames Under Atmospheric Pressure

Energies
We present a combined experimental and modeling study of premixed atmospheric-pressure tetralin flames. Chemical speciation in near-stoichiometric (φ = 0.8–1.0) tetralin/O2/Ar flames was characterized by probe-sampling molecular-beam mass spectrometry ...
Vladislav V. Matyushkov, Anatoly A. Chernov, Mikhail V. Novikov, Ksenia N. Osipova, Tatyana A. Bolshova, Artëm M. Dmitriev, Denis A. Knyazkov, Andrey G. Shmakov   +7 more
doaj   +1 more source

Kinetic inductance magnetometer [PDF]

Nature Communications, 2014
Ultrasensitive magnetic field detection is utilized in the fields of science, medicine and industry. We report on a novel magnetometer relying on the kinetic inductance of superconducting material. The kinetic inductance exhibits a non-linear response with respect to DC current, a fact that is exploited by applying magnetic flux through a ...
Vesterinen, Visa, Grönberg, Leif, Hassel, Juha, Luomahaara, Juho   +4 more
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source