Results 321 to 330 of about 411,207 (359)
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Kinetics of lysozyme-substrate interactions
Biochemical and Biophysical Research Communications, 1969Abstract Presteady state kinetics of the interaction of lysozyme with the hexamer and trimer of N-acetylglucosamine have been investigated by stopped-flow and relaxation methods. Two processes were observed with hexamer, and only one with trimer. The processes for hexamer were observed either as two consecutive proton uptake signals or as a fast ...
E, Holler, J A, Rupley, G P, Hess
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Interaction of Perphenazine with the Kinetics of Nortriptyline
Acta Pharmacologica et Toxicologica, 1977AbstractThe kinetics of nortriptyline in four patients were investigated before and during treatment with perphenazine (24–36 mg/day) by administering 57 mg nortriptyline hydrochloride as an intravenous infusion and evaluating the resulting plasma concentration data according to a two compartment open model. In all patients an increased biological half‐
K F, Overo, L F, Gram, V, Hansen
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Kinetics of the daunomycin-DNA interaction
Biochemistry, 1985The kinetics of the interaction of daunomycin with calf thymus DNA are described. Stopped-flow and temperature-jump relaxation methods, using absorption detection, were used to study the binding reaction. Three relaxation times were observed, all of which are concentration dependent, although the two slower relaxations approach constant values at high ...
J B, Chaires +2 more
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Kinetics of drug displacement interactions
Journal of Pharmacokinetics and Biopharmaceutics, 1981A simple model simulating the kinetics of drugs displacement kinetics is investigated. It is demonstrated that for highly bound, lowly cleared drugs, displacement interactions are transitory. Consequently, the kinetics of the interaction have to be considered as well as the in vitro interaction.
L J, Aarons, M, Rowland
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Kinetics of a carbamazepine-ethosuximide interaction
Clinical Pharmacology and Therapeutics, 1980Carbamazepine and ethosuximide are used together to treat epileptic mixed-seizure patterns. Since carbamazepine has been shown to induce drug-metabolizing enzyme(s) in the liver, it follows that carbamazepine may alter ethosuximide disposition. Six normal subjects took one 250-mg ethosuximide capsule twice each day for 55 consecutive doses (study days ...
J W, Warren +3 more
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Kinetic Profile of Neuropeptide–Receptor Interactions
Trends in Neurosciences, 2016Currently, drug discovery focusses only on quantifying pharmacological parameters, sometimes including binding kinetics, of drug candidates. For a complete understanding of a drug's desired binding kinetics, the kinetics of both the target and its endogenous ligands should be considered.
Nederpelt +4 more
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Kinetics of Antibody-Hapten Interactions
1977The immune system, which is the major defence complex present in vertebrates against foreign cells and pathogens, is comprised of lymphocytes and their products, the antibodies. The latter carry out the function of recognition of antigenic determinants and the resultant triggering of a wide range of biological responses.
I, Pecht, D, Lancet
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Kinetics of biomolecular interactions
Expert Opinion on Therapeutic Patents, 1997Recent advances in instrumentation, in particular the development of biosensors, have greatly simplified the measurement of the kinetics of molecular interactions. Previously, while it was realised that the kinetics of biomolecular interactions were important factors in the successful design of molecules for clinical, industrial or scientific purposes,
Andrew JT George +2 more
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Kinetics of interaction of ligands with carboxypeptidase A
Journal of Inorganic Biochemistry, 1979Rate constants for the interaction of a number of ligands with the active site zinc ion of carboxypeptidase A have been measured at pH 7.0, 25 degrees, 1.0 M NaCl. Polydentate ligands such as EDTA, NTA or CyDta do not accelerate the rate at which the zinc ion dissociates from the protein.
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1987
Most of the theoretical detail contained in this monograph is confined to this chapter. Here is discussed the interaction of electromagnetic radiation, from the ultraviolet through the visible to the near infrared, with matter. The treatment of laser excitation of gases and solids through vibrational and electronic transitions, and the subsequent ...
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Most of the theoretical detail contained in this monograph is confined to this chapter. Here is discussed the interaction of electromagnetic radiation, from the ultraviolet through the visible to the near infrared, with matter. The treatment of laser excitation of gases and solids through vibrational and electronic transitions, and the subsequent ...
openaire +1 more source